The transcription factor nuclear factor erythroid-derived 2-like 2 (NRF2) participates in the
activation of the antioxidant cytoprotective pathway and other important physiological …

Apoptosis is an evolutionarily conserved and tightly regulated cell death pathway.
Physiological cell death is important for maintaining homeostasis and optimal biological …

Alzheimer's disease (AD) is a highly age-related cognitive decline frequently attacking the
elderly. Senescence-accelerated mouse-prone 8 (SAMP8) is an ideal model to study AD …

Neurological disorders are a group of disorders with motor, sensory or cognitive damage,
caused by dysfunction of the central or peripheral nervous system. Cyclin-dependent …

Delayed oligodendrocyte (OL) maturation caused by hypoxia (Hx)-induced neonatal brain
injury results in hypomyelination and leads to neurological disabilities. Previously, we …

Abstract Cyclin-dependent kinase 5 (CDK5) is the serine/threonine-directed kinase mainly
found in the brain and plays a significant role in developing the central nervous system …

Calcium channel TRPV6 upregulation is associated with poor prognosis of breast cancer by
promoting invasion and metastasis, and TRPV6 is a potential target for breast cancer …

Neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and
Huntington's disease, present challenges in healthcare because of their complicated …

Simple Summary CDK5 is a serine/threonine type kinase that is mainly found in nerves. It is
a target that has been studied primarily in neurological disorders, but recently it has been …

This review postulates that age-related neurodegeneration entails inappropriate activation
of intrinsic pathways to enable brain plasticity through deregulated calcium (Ca2+) …