More than one-third of the worldwide population is overweight or obese and therefore at risk
of developing type 2 diabetes mellitus. In order to mitigate this pandemic, safer and more …

Lipids are the predominant source of energy for fish. The mechanisms by which fish allocate
energy from lipids for metabolism, development, growth, and reproduction are critical for …

Leptin is the primary adipostatic factor in mammals. Produced largely by adipocytes in
proportion to total adipose mass, the hormone informs the brain regarding total energy …

Polycystic ovarian syndrome (PCOS) causes swollen ovaries in women at reproductive age
due to hormonal disorder with small cysts on the outer edges. The cause of the disorder is …

Since its introduction as a genetic vertebrate model system approximately 30 years ago, the
focus of zebrafish research has increasingly shifted to questions that are also relevant for …

Müller glia (MG) in the zebrafish retina respond to retinal injury by generating multipotent
progenitors for retinal repair. Here, we show that Insulin, Igf-1, and fibroblast growth factor …

Bisphenol A (BPA) is an endocrine disruptor used in manufacturing of plastic devices,
resulting in an ubiquitous presence in the environment linked to human infertility, obesity or …

Fish have provided essential information about the structure, biosynthesis, evolution, and
function of insulin (INS) as well as about the structure, evolution, and mechanism of action of …

Abstract Development of the vertebrate pancreas is a complex stepwise process comprising
regionalization, cell differentiation, and morphogenesis. Studies in zebrafish are contributing …

Background: Aberrant signaling between germ cells and somatic cells can lead to
reproductive disease and depends on diffusible signals, including transforming growth factor …