The multifaceted nature of antimicrobial peptides: Current synthetic chemistry approaches and future directions

BH Gan, J Gaynord, SM Rowe, T Deingruber… - Chemical Society …, 2021 - pubs.rsc.org
Bacterial infections caused by 'superbugs' are increasing globally, and conventional
antibiotics are becoming less effective against these bacteria, such that we risk entering a …

Antimicrobial peptides: Structure, mechanism, and modification

N Chen, C Jiang - European Journal of Medicinal Chemistry, 2023 - Elsevier
From the 1940s to the 1960s, the discovery of antibiotics held substantial promise for the
treatment of bacterial infection, and it was also widely used in food, agriculture, and other …

Antimicrobial peptides as potential alternatives to antibiotics in food animal industry

S Wang, X Zeng, Q Yang, S Qiao - International journal of molecular …, 2016 - mdpi.com
Over the last decade, the rapid emergence of multidrug-resistant pathogens has become a
global concern, which has prompted the search for alternative antibacterial agents for use in …

Designing antimicrobial peptides: form follows function

CD Fjell, JA Hiss, REW Hancock… - Nature reviews Drug …, 2012 - nature.com
Multidrug-resistant bacteria are a severe threat to public health. Conventional antibiotics are
becoming increasingly ineffective as a result of resistance, and it is imperative to find new …

[HTML][HTML] Antimicrobial peptides as a feed additive alternative to animal production, food safety and public health implications: An overview

RF Silveira, CA Roque-Borda, EF Vicente - Animal Nutrition, 2021 - Elsevier
In the last few years, feed additives have been used in animal nutrition to improve nutrient
utilization, health parameters and animal performance. However, the use of antibiotics as …

Insect cecropins, antimicrobial peptides with potential therapeutic applications

D Brady, A Grapputo, O Romoli, F Sandrelli - International journal of …, 2019 - mdpi.com
The alarming escalation of infectious diseases resistant to conventional antibiotics requires
urgent global actions, including the development of new therapeutics. Antimicrobial peptides …

Amphipathic, α‐helical antimicrobial peptides

A Tossi, L Sandri, A Giangaspero - Peptide Science, 2000 - Wiley Online Library
Gene‐encoded antimicrobial peptides are an important component of host defense in
animals ranging from insects to mammals. They do not target specific molecular receptors …

Identification of the bactericidal domain of lactoferrin

W Bellamy, M Takase, K Yamauchi… - … et Biophysica Acta (BBA …, 1992 - Elsevier
We report the existence of a previously unknown antimicrobial domain near the N-terminus
of lactoferrin in a region distinct from its iron-binding sites. A single active peptide …

Mode of action of linear amphipathic α‐helical antimicrobial peptides

Z Oren, Y Shai - Peptide Science, 1998 - Wiley Online Library
The increasing resistance of bacteria to conventional antibiotics resulted in a strong effort to
develop antimicrobial compounds with new mechanisms of action. Antimicrobial peptides …

[HTML][HTML] Structural features of helical antimicrobial peptides: their potential to modulate activity on model membranes and biological cells

M Dathe, T Wieprecht - Biochimica et Biophysica Acta (BBA) …, 1999 - Elsevier
Antibacterial, membrane-lytic peptides belong to the innate immune system and host
defense mechanism of a multitude of animals and plants. The largest group of peptide …