Blood biomarkers for brain injury: What are we measuring?
K Kawata, CY Liu, SF Merkel, SH Ramirez… - Neuroscience & …, 2016 - Elsevier
Accurate diagnosis for mild traumatic brain injury (mTBI) remains challenging, as prognosis
and return-to-play/work decisions are based largely on patient reports. Numerous …
and return-to-play/work decisions are based largely on patient reports. Numerous …
S100B in brain damage and neurodegeneration
M Rothermundt, M Peters, JHM Prehn… - … research and technique, 2003 - Wiley Online Library
S100B is a calcium‐binding peptide produced mainly by astrocytes that exert paracrine and
autocrine effects on neurons and glia. Some knowledge has been acquired from in vitro and …
autocrine effects on neurons and glia. Some knowledge has been acquired from in vitro and …
GFAP and S100B are biomarkers of traumatic brain injury: an observational cohort study
PE Vos, B Jacobs, T Andriessen, KJB Lamers… - Neurology, 2010 - AAN Enterprises
Background: Biomarker levels in blood after traumatic brain injury (TBI) may offer diagnostic
and prognostic tools in addition to clinical indices. This study aims to validate glial fibrillary …
and prognostic tools in addition to clinical indices. This study aims to validate glial fibrillary …
The S100B protein in biological fluids: more than a lifelong biomarker of brain distress
F Michetti, V Corvino, MC Geloso… - Journal of …, 2012 - Wiley Online Library
J. Neurochem.(2012) 120, 644–659. Abstract S100B is a calcium‐binding protein
concentrated in glial cells, although it has also been detected in definite extra‐neural cell …
concentrated in glial cells, although it has also been detected in definite extra‐neural cell …
Glial and neuronal proteins in serum predict outcome after severe traumatic brain injury
PE Vos, KJB Lamers, JCM Hendriks, M Van Haaren… - Neurology, 2004 - AAN Enterprises
Objective: To study the ability of glial (glial fibrillary acidic protein [GFAP] and S100b) and
neuronal (neuron specific enolase [NSE]) protein levels in peripheral blood to predict …
neuronal (neuron specific enolase [NSE]) protein levels in peripheral blood to predict …
Interrater reliability of Glasgow Coma Scale scores in the emergency department
MR Gill, DG Reiley, SM Green - Annals of emergency medicine, 2004 - Elsevier
STUDY OBJECTIVE: Emergency physicians often use the Glasgow Coma Scale (GCS) to
help guide decisions in patient care, yet the reliability of the GCS has never been tested in a …
help guide decisions in patient care, yet the reliability of the GCS has never been tested in a …
Serum S-100B concentration provides additional information fot the indication of computed tomography in patients after minor head injury: a prospective multicenter …
P Biberthaler, U Linsenmeier, KJ Pfeifer, M Kroetz… - Shock, 2006 - journals.lww.com
Ninety percent of patients with minor head injury (MHI) who have cranial computed
tomography (CCT) under the present clinical decision rules have normal scans. Serum …
tomography (CCT) under the present clinical decision rules have normal scans. Serum …
Changes in CSF S100B and cytokine concentrations in early-phase severe traumatic brain injury
T Hayakata, T Shiozaki, O Tasaki, H Ikegawa, Y Inoue… - Shock, 2004 - journals.lww.com
Abstract S100B protein (S100B) has been described as a marker of brain injury. Various
cytokines also increase in the cerebrospinal fluid (CSF) of patients with severe traumatic …
cytokines also increase in the cerebrospinal fluid (CSF) of patients with severe traumatic …
Blood-based diagnostics of traumatic brain injuries
S Mondello, U Muller, A Jeromin, J Streeter… - Expert review of …, 2011 - Taylor & Francis
Traumatic brain injury is a major health and socioeconomic problem that affects all societies.
However, traditional approaches to the classification of clinical severity are the subject of …
However, traditional approaches to the classification of clinical severity are the subject of …
S100-B protein as a screening tool for the early assessment of minor head injury
D Zongo, R Ribéreau-Gayon, F Masson… - Annals of emergency …, 2012 - Elsevier
STUDY OBJECTIVE: A computed tomography (CT) scan has high sensitivity in detecting
intracranial injury in patients with minor head injury but is costly, exposes patients to high …
intracranial injury in patients with minor head injury but is costly, exposes patients to high …