Implications of microbiota and bile acid in liver injury and regeneration

HX Liu, R Keane, L Sheng, YJY Wan - Journal of hepatology, 2015 - Elsevier
Studies examining the mechanisms by which the liver incurs injury and then regenerates
usually focus on factors and pathways directly within the liver, neglecting the signaling …

The role of gut microbiota in liver regeneration

Z Xu, N Jiang, Y Xiao, K Yuan, Z Wang - Frontiers in Immunology, 2022 - frontiersin.org
The liver has unique regeneration potential, which ensures the continuous dependence of
the human body on hepatic functions. As the composition and function of gut microbiota has …

Gender differences in bile acids and microbiota in relationship with gender dissimilarity in steatosis induced by diet and FXR inactivation

L Sheng, PK Jena, HX Liu, KM Kalanetra… - Scientific reports, 2017 - nature.com
This study aims to uncover how specific bacteria and bile acids (BAs) contribute to steatosis
induced by diet and farnesoid X receptor (FXR) deficiency in both genders. A control diet …

[HTML][HTML] Retinoids in health and disease: a role for hepatic stellate cells in affecting retinoid levels

MW Haaker, AB Vaandrager, JB Helms - Biochimica et Biophysica Acta …, 2020 - Elsevier
Vitamin A (retinol) is important for normal growth, vision and reproduction. It has a role in the
immune response and the development of metabolic syndrome. Most of the retinol present …

Functional analysis of the relationship between intestinal microbiota and the expression of hepatic genes and pathways during the course of liver regeneration

HX Liu, CS Rocha, S Dandekar, YJY Wan - Journal of hepatology, 2016 - Elsevier
Background & Aims The pathways regulating liver regeneration have been extensively
studied within the liver. However, the signaling contribution derived from the gut microbiota …

Targeting fatty acid metabolism for fibrotic disorders

S Hwang, KW Chung - Archives of pharmacal research, 2021 - Springer
Fibrosis is defined by abnormal accumulation of extracellular matrix, which can affect
virtually every organ system under diseased conditions. Fibrotic tissue remodeling often …

Current knowledge about the effect of nutritional status, supplemented nutrition diet, and gut microbiota on hepatic ischemia-reperfusion and regeneration in liver …

ME Cornide-Petronio, AI Álvarez-Mercado… - Nutrients, 2020 - mdpi.com
Ischemia-reperfusion (I/R) injury is an unresolved problem in liver resection and
transplantation. The preexisting nutritional status related to the gut microbial profile might …

A selenium-containing ruthenium complex as a cancer radiosensitizer, rational design and the important role of ROS-mediated signalling

Z Deng, L Yu, W Cao, W Zheng, T Chen - Chemical Communications, 2015 - pubs.rsc.org
A novel selenium-containing ruthenium complex Ru (phtpy)(phenSe) Cl (ClO4)(phtpy= 4-
phenyl-2, 2′: 6′, 2′′-terpyridine, phenSe= 2-selenicimidazole [4, 5-f] 1, 10 …

PPAR-gamma activation is associated with reduced liver ischemia-reperfusion injury and altered tissue-resident macrophages polarization in a mouse model

I Linares, K Farrokhi, J Echeverri, JM Kaths… - PLoS …, 2018 - journals.plos.org
Background PPAR-gamma (γ) is highly expressed in macrophages and its activation affects
their polarization. The effect of PPAR-γ activation on Kupffer cells (KCs) and liver ischemia …

[HTML][HTML] Liver regeneration and ethanol detoxification: a new link in YAP regulation of ALDH1A1 during alcohol‐related hepatocyte damage

J Zhou, C Sun, L Yang, J Wang, N Jn‐Simon… - The FASEB …, 2022 - ncbi.nlm.nih.gov
Abstract Yes‐associated protein (YAP), a central effector in the Hippo pathway, is involved in
the regulation of organ size, stem cell self‐renewal, and tissue regeneration. In this study …