Inflammasomes are large protein complexes that play a major role in sensing inflammatory
signals and triggering the innate immune response. Each inflammasome complex has three …

Innate immune receptors initiate a host immune response, or inflammatory response, upon
detecting pathogen-associated molecular patterns (PAMPs) and damage-associated …

Nucleotide-binding oligomerization domain (NOD)-like receptors, also known as nucleotide-
binding leucine-rich repeat receptors (NLRs), are a family of cytosolic pattern recognition …

Cytosolic innate immune sensing is a cornerstone of innate immunity in mammalian cells
and provides a surveillance system for invading pathogens and endogenous danger …

Monogenic autoinflammatory diseases are a group of rheumatologic disorders caused by
dysregulation in the innate immune system. The molecular mechanisms of these disorders …

Chronic inflammation is recognized as a major risk factor for cancer and is involved in every
phase of the disease. Inflammasomes are central to the inflammatory response and play a …

Introduction: Primary immunodeficiency diseases (PIDs) are under-reported in Malaysia.
The actual disease frequency of PID in this country is unknown due to the absence of a …

Review: Interleukin-18 (IL-18) is a proinflammatory cytokine that promotes various innate
immune processes related to infection, inflammation, and autoimmunity. Patients with …

Inflammasomes are macromolecular complexes involved in the host response to external
and endogenous danger signals. Inflammasome-mediated sterile inflammation plays a …

The NLRC4 inflammasome is part of the human immune innate system. Its activation leads
to the cleavage of pro-inflammatory cytokines IL-1β and IL-18, promoting inflammation …