Animal models of depression: what can they teach us about the human disease?

M Becker, A Pinhasov, A Ornoy - Diagnostics, 2021 - mdpi.com
Depression is apparently the most common psychiatric disease among the mood disorders
affecting about 10% of the adult population. The etiology and pathogenesis of depression …

Role of neuropeptides in anxiety, stress, and depression: from animals to humans

V Kormos, B Gaszner - Neuropeptides, 2013 - Elsevier
Major depression, with its strikingly high prevalence, is the most common cause of disability
in communities of Western type, according to data of the World Health Organization. Stress …

Potential gut–brain mechanisms behind adverse mental health outcomes of bariatric surgery

RM Brown, E Guerrero-Hreins, WA Brown… - Nature Reviews …, 2021 - nature.com
Bariatric surgery induces sustained weight loss and metabolic benefits via notable effects on
the gut–brain axis that lead to alterations in the neuroendocrine regulation of appetite and …

[HTML][HTML] Targeting the neuropeptide Y system in stress-related psychiatric disorders

NM Enman, EL Sabban, P McGonigle… - Neurobiology of …, 2015 - Elsevier
Repeated, extreme, or traumatic stressors can elicit pathological effects leading to many
negative physical and psychological outcomes. Stressors can precipitate the onset of …

Neuropeptide Y and posttraumatic stress disorder

R Sah, TD Geracioti - Molecular psychiatry, 2013 - nature.com
Resiliency to the adverse effects of extraordinary emotional trauma on the brain varies within
the human population. Accordingly, some people cope better than others with traumatic …

[HTML][HTML] Reinstating olfactory bulb-derived limbic gamma oscillations alleviates depression-like behavioral deficits in rodents

Q Li, Y Takeuchi, J Wang, L Gellért, L Barcsai… - Neuron, 2023 - cell.com
Although the etiology of major depressive disorder remains poorly understood, reduced
gamma oscillations is an emerging biomarker. Olfactory bulbectomy, an established model …

The olfactory bulbectomized rat as a model of depression: the hippocampal pathway

JC Morales-Medina, T Iannitti, A Freeman… - Behavioural Brain …, 2017 - Elsevier
In rodents, the removal of the olfactory bulbs (OBs), ie olfactory bulbectomy (OBX), results in
numerous alterations in neurotransmitter, endocrine and immune systems, as well as …

The microbiota-gut-brain axis in pathogenesis of depression: A narrative review

H Yao, D Zhang, H Yu, H Shen, H Liu, F Meng… - Physiology & …, 2023 - Elsevier
The microbiota-gut-brain axis is a bidirectional regulatory pathway between the brain and
the gastrointestinal tract, which plays an important role in maintain homeostasis. Gut …

Neuropeptide Y in the medial habenula alleviates migraine-like behaviors through the Y1 receptor

C Yang, Z Gong, X Zhang, S Miao, B Li, W Xie… - The Journal of …, 2023 - Springer
Background Migraine is a highly disabling health burden with multiple symptoms; however,
it remains undertreated because of an inadequate understanding of its neural mechanisms …

Basolateral amygdala neuropeptide Y system modulates binge ethanol consumption

SL Robinson, SC Bendrath, EM Yates… - …, 2024 - nature.com
Neuropeptide Y (NPY) signaling regulation of corticolimbic communication is known to
modulate binge-like ethanol consumption in rodents. In this work we sought to assess the …