Orofacial clefts include cleft lip (CL), cleft palate (CP), and cleft lip and palate (CLP), which
combined represent the largest group of craniofacial malformations in humans with an …

Historically, craniofacial genetic research has understandably focused on identifying the
causes of craniofacial anomalies and it has only been within the last 10 years, that there has …

Non-syndromic cleft lip with palate (NSCLP) is the most serious sub-phenotype of non-
syndromic orofacial clefts (NSOFC), which are the most common craniofacial birth defects in …

The terminal differentiation of osteoblasts and subsequent formation of bone marks an
important phase in palate development that leads to the separation of the oral and nasal …

Orofacial clefts (OFCs), which include non-syndromic cleft lip with or without cleft palate
(CL/P), are among the most common birth defects in humans, affecting approximately 1 in …

Nonsyndromic cleft lip with or without a cleft palate (NSCL/P) is among the most common
human congenital birth defects and imposes a substantial physical and financial burden on …

Nonsyndromic orofacial clefts (OFCs) are a heterogeneous group of common craniofacial
birth defects with complex etiologies that include genetic and environmental risk factors …

Variations in the form of the human face, which plays a role in our individual identities and
societal interactions, have fascinated scientists and artists alike. Here, we review our current …

Clefts of the lip and palate (CLP), the major causes of congenital facial malformation
globally, result from failure of fusion of the facial processes during embryogenesis. With a …

Although genome-wide association studies (GWASs) for nonsyndromic orofacial clefts have
identified multiple strongly associated regions, the causal variants are unknown. To address …