Phosphoinositides as membrane organizers
Phosphoinositides are signalling lipids derived from phosphatidylinositol, a ubiquitous
phospholipid in the cytoplasmic leaflet of eukaryotic membranes. Initially discovered for their …
phospholipid in the cytoplasmic leaflet of eukaryotic membranes. Initially discovered for their …
Beyond PI3Ks: targeting phosphoinositide kinases in disease
JE Burke, J Triscott, BM Emerling… - Nature Reviews Drug …, 2023 - nature.com
Lipid phosphoinositides are master regulators of almost all aspects of a cell's life and death
and are generated by the tightly regulated activity of phosphoinositide kinases. Although …
and are generated by the tightly regulated activity of phosphoinositide kinases. Although …
[HTML][HTML] Membrane phosphoinositides regulate GPCR-β-arrestin complex assembly and dynamics
Binding of arrestin to phosphorylated G protein-coupled receptors (GPCRs) is crucial for
modulating signaling. Once internalized, some GPCRs remain complexed with β-arrestins …
modulating signaling. Once internalized, some GPCRs remain complexed with β-arrestins …
PI4KA and PIKfyve: Essential phosphoinositide signaling enzymes involved in myriad human diseases
Lipid phosphoinositides are master regulators of multiple cellular functions. Misregulation of
the activity of the lipid kinases that generate phosphoinositides is causative of human …
the activity of the lipid kinases that generate phosphoinositides is causative of human …
Phosphoinositides: regulators of nervous system function in health and disease
Phosphoinositides, the seven phosphorylated derivatives of phosphatidylinositol have
emerged as regulators of key sub-cellular processes such as membrane transport …
emerged as regulators of key sub-cellular processes such as membrane transport …
Segregated cation flux by TPC2 biases Ca2+ signaling through lysosomes
Two-pore channels are endo-lysosomal cation channels with malleable selectivity filters that
drive endocytic ion flux and membrane traffic. Here we show that TPC2 can differentially …
drive endocytic ion flux and membrane traffic. Here we show that TPC2 can differentially …
A family of PIKFYVE inhibitors with therapeutic potential against autophagy-dependent cancer cells disrupt multiple events in lysosome homeostasis
High-throughput screening identified 5 chemical analogs (termed the WX8-family) that
disrupted 3 events in lysosome homeostasis:(1) lysosome fission via tubulation without …
disrupted 3 events in lysosome homeostasis:(1) lysosome fission via tubulation without …
[HTML][HTML] Recent advances in understanding the molecular basis of melanogenesis in melanocytes
N Ohbayashi, M Fukuda - F1000Research, 2020 - ncbi.nlm.nih.gov
Melanin pigments are responsible for human skin and hair color, and they protect the body
from harmful ultraviolet light. The black and brown melanin pigments are synthesized in …
from harmful ultraviolet light. The black and brown melanin pigments are synthesized in …
Insights into lysosomal PI (3, 5) P2 homeostasis from a structural-biochemical analysis of the PIKfyve lipid kinase complex
JA Lees, PQ Li, N Kumar, LS Weisman, KM Reinisch - Molecular cell, 2020 - cell.com
Summary The phosphoinositide PI (3, 5) P 2, generated exclusively by the PIKfyve lipid
kinase complex, is key for lysosomal biology. Here, we explore how PI (3, 5) P 2 levels …
kinase complex, is key for lysosomal biology. Here, we explore how PI (3, 5) P 2 levels …
Cytoplasmic short linear motifs in ACE2 and integrin β3 link SARS-CoV-2 host cell receptors to mediators of endocytosis and autophagy
J Kliche, H Kuss, M Ali, Y Ivarsson - Science signaling, 2021 - science.org
The spike protein of SARS-CoV-2 binds the angiotensin-converting enzyme 2 (ACE2) on the
host cell surface and subsequently enters host cells through receptor-mediated endocytosis …
host cell surface and subsequently enters host cells through receptor-mediated endocytosis …