Epilepsy is a severely debilitating brain disease, often associated with premature death,
which has an urgent need for alternative methods of treatment. In fact, roughly 25% of …

Rationalized development of electrical stimulation (ES) therapy is of paramount importance.
Not only it will foster new techniques and technologies with increased levels of safety …

Many patients with epilepsy do not obtain proper control of their seizures through
conventional treatment. We review aspects of the pathophysiology underlying epileptic …

The idea of the epileptic brain being highly excitable and facilitated to synchronic activity has
guided pharmacological treatment since the early twentieth century. Although tackling …

Deep brain stimulation (DBS) of the anterior nucleus of the thalamus (ANT) is a safe and
effective intervention for the treatment of certain forms of epilepsy. In preclinical models …

Objective To investigate the abortion of seizure generation using “minimal” intervention in
hippocampi using two rat models of human temporal lobe epilepsy. Methods The recording …

To effectively study the mechanisms by which deep brain stimulation (DBS) produces its
therapeutic benefit and to evaluate new therapeutic indications, it is vital to administer DBS …

Based on the rationale that neural hypersynchronization underlies epileptic phenomena,
nonperiodic stimulation (NPS) was designed and successfully tested as an electrical …

Electrical stimulation of the central nervous system is a promising alternative for the
treatment of pharmacoresistant epilepsy. Successful clinical and experimental stimulation is …

A promising alternative for the treatment of refractory epilepsy is electrical stimulation (ES) of
the central nervous system. Based on the premise that epilepsy is a result of neural …