According to Genome Sequencing Project statistics (http://www. ncbi. nlm. nih.
gov/genomes/static/gpstat. html), as of February 16, 2012, complete gene sequences have …

Mass spectrometry (MS) is the most comprehensive and versatile tool in large-scale
proteomics. In this review, we dissect the overall framework of the MS experiment into its key …

Abstract Superoxide dismutase 1 (Sod1) has been known for nearly half a century for
catalysis of superoxide to hydrogen peroxide. Here we report a new Sod1 function in …

When non-mass spectrometrists are talking about mass spectrometry it rather often sounds
as if they were telling a story out of Poe's Tales of Mystery and Imagi-tion. Indeed, mass …

Mass spectrometry (MS)-based phosphoproteomics has achieved extraordinary success in
qualitative and quantitative analysis of cellular protein phosphorylation. Considering that an …

Mass spectrometry has been widely used to analyze biological samples and has evolved
into an indispensable tool for proteomics research. Our desire to understand the proteome …

The interactions of protein kinases and phosphatases with their regulatory subunits and
substrates underpin cellular regulation. We identified a kinase and phosphatase interaction …

In-depth structural characterization of lipids is an essential component of lipidomics. There
has been a rapid expansion of mass spectrometry methods that are capable of resolving …

Mass spectrometry (MS)-based proteomics has become the preferred tool for the analysis of
protein phosphorylation. To be successful at such an endeavor, there is a requirement for an …

Post-translational modifications of proteins control many biological processes, and
examining their diversity is critical for understanding mechanisms of cell regulation. Mass …