Cachexia, a systemic wasting condition, is considered a late consequence of diseases,
including cancer, organ failure, or infections, and contributes to significant morbidity and …

Endocrine mechanisms have been largely associated with metabolic control and tissue
cross talk in mammals. Classically, myokines comprise a class of signaling proteins …

The ability to map trafficking for thousands of endogenous proteins at once in living cells
would reveal biology currently invisible to both microscopy and mass spectrometry. Here, we …

There is a significant interest in identifying blood-borne factors that mediate tissue crosstalk
and function as molecular effectors of physical activity. Although past studies have focused …

Proximity labeling (PL) with genetically-targeted promiscuous enzymes has emerged as a
powerful tool for unbiased proteome discovery. By combining the spatiotemporal specificity …

Cell-surface proteins (CSPs) mediate intercellular communication throughout the lives of
multicellular organisms. However, there are no generalizable methods for quantitative CSP …

Proteogenomic identification of translated small open reading frames has revealed
thousands of previously unannotated, largely uncharacterized microproteins, or …

Secretory proteins are an essential component of interorgan communication networks that
regulate animal physiology. Current approaches for identifying secretory proteins from …

Single‐cell RNA sequencing (scRNA‐seq) has emerged as a powerful tool for investigating
cell states and functions at the single‐cell level. It has greatly revolutionized transcriptomic …

Infections and neurodegenerative diseases induce neuroinflammation, but affected
individuals often show nonneural symptoms including muscle pain and muscle fatigue. The …