Phosphoinositides are signalling lipids derived from phosphatidylinositol, a ubiquitous
phospholipid in the cytoplasmic leaflet of eukaryotic membranes. Initially discovered for their …

Organelles compartmentalize eukaryotic cells, enhancing their ability to respond to
environmental and developmental changes. One way in which organelles communicate and …

Soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) are a
family of small conserved eukaryotic proteins that mediate membrane fusion between …

Small GTPases use GDP/GTP alternation to actuate a variety of functional switches that are
pivotal for cell dynamics. The GTPase switch is turned on by GEFs, which stimulate …

Being deeply connected to signalling, cell dynamics, growth, regulation, and defence,
endocytic processes are linked to almost all aspects of cell life and disease. In this review …

Lipid composition determines organelle identity; however, whether the lipid composition of
the inner nuclear membrane (INM) domain of the ER contributes to its identity is not known …

Defects in membrane trafficking are hallmarks of neurodegeneration. Rab GTPases are key
regulators of membrane trafficking. Alterations of Rab GTPases, or the membrane …

Although lipids are biomolecules with seemingly simple chemical structures, the molecular
composition of the cellular lipidome is complex and, currently, poorly understood. The exact …

Inositol phospholipids have long been known to have an important regulatory role in cell
physiology. The repertoire of cellular processes known to be directly or indirectly controlled …

Lysosomes are dynamic organelles that receive and degrade macromolecules from the
secretory, endocytic, autophagic and phagocytic membrane-trafficking pathways. Live-cell …