Abstract Ras-associated protein-1 (Rap1), a small GTPase in the Ras-related protein family,
is an important regulator of basic cellular functions (eg, formation and control of cell …

Abstract Background Although Mex3 RNA‐binding family member A (Mex3a) has
demonstrated an important role in multiple cancers, its role and regulatory mechanism in …

Illustrated here is the critical role of oncogenic KRAS in the initiation of cancer through
deregulation of the G1 cell cycle, and elements and scenarios taking place under …

Rap, a member of the Ras-like small G-protein family, is a key node among G-protein
coupled receptors (GPCR), receptor tyrosine kinases (RTKs), ion channels and many other …

Vascular lumen formation is a fundamental step during angiogenesis; yet, the molecular
mechanisms underlying this process are poorly understood. Recent studies have shown that …

Background Physical forces, such as mechanical stress, are essential for tissue homeostasis
and influence gene expression of cells. In particular, the fibroblast has demonstrated …

Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children and
adolescents. Alveolar (ARMS) and embryonal (ERMS) histologies predominate, but rare …

Tobacco smoke (TS) is the leading cause for lung cancer (LC), and female smokers are at a
greater risk for LC. Yet, the underlying causes are unknown. We performed whole genome …

Diagnosis of breast ductal carcinoma in situ (DCIS) presents a challenge since we cannot
yet distinguish those cases that would remain indolent and not require aggressive treatment …

Clathrin heavy chain is the structural component of the clathrin triskelion, but unique
functions for the two distinct and highly conserved clathrin light chains (CLCa and CLCb …