The mechanistic target of rapamycin (mTOR), master regulator of cellular metabolism, exists
in two distinct complexes: mTOR complex 1 and mTOR complex 2 (mTORC1 and 2) …

Autophagy is a highly conserved catabolic process and a major cellular pathway for the
degradation of long-lived proteins and cytoplasmic organelles. An increasing body of …

Background: Although inhibition of SGK1 has been shown to delay cancer progression, the
underlying mechanisms have not yet been elucidated. Methods: We investigated the cellular …

Mitogen-activated protein kinases (MAP kinases) are a family of kinases that regulates a
range of biological processes implicated in the response to growth factors like latelet …

Serum and glucocorticoid-induced protein kinase 1 (SGK1) is a member of the “AGC”
subfamily of protein kinases, which shares structural and functional similarities with the AKT …

Patients with severe chronic graft-versus-host disease (cGVHD) always experience
debilitating tissue injury and have poorer quality of life and shorter survival time. The early …

Simple Summary In just less than 30 years since the cloning of RANBP1 (RAN binding
protein 1), this review represents the first attempt for a comprehensive and analytical …

Serum-and glucocorticoid-regulated kinases (SGKs) are members of the AGC family of
serine/threonine kinases, consisting of three isoforms: SGK1, SGK2, and SGK3. SGK1 was …

Serum and glucocorticoid-inducible kinase 1 (SGK1) is an AGC kinase that has been
reported to be involved in a variety of physiological and pathological processes. Recent …

Endometrium is the mucosal lining of the uterus which expressed a cyclic process of
proliferation, secretion and scaling under the control of hormones secreted by the ovary, and …