New Delhi metallo-β-lactamase (NDM) is a metallo-β-lactamase able to hydrolyze almost all
β-lactams. Twenty-four NDM variants have been identified in> 60 species of 11 bacterial …

The dramatic global rise of MDR and XDR Enterobacterales in human medicine forced
clinicians to the reintroduction of colistin as last-resort drug. Meanwhile, colistin is used in …

Following their initial discovery in the 1940s, polymyxin antibiotics fell into disfavor due to
their potential clinical toxicity, especially nephrotoxicity. However, the dry antibiotic …

Modern medicine is threatened by the rising tide of antimicrobial resistance, especially
among Gram-negative bacteria, where resistance to β-lactams is most often mediated by β …

Until recently, the polymyxin antibiotics were used sparingly due to dose limiting toxicities.
However, the lack of therapeutic alternatives for infections caused by highly resistant Gram …

In the last decade, extended-spectrum cephalosporin and carbapenem resistant Gram-
negative bacilli (GNB) have been extensively reported in the literature as being …

Antimicrobial resistance (AMR) is a global public-health emergency, which threatens the
advances made by modern medical care over the past century. The World Health …

Colistin-resistant multidrug-resistant (MDR), extensively drug-resistant (XDR), and pan-drug-
resistant (PDR) bacteria are highly lethal and many researchers have tried hard to combat …

Purpose Microbial coinfections in COVID-19 patients carry a risk of poor outcomes. This
study aimed to characterize the clinical and microbiological profiles of coinfections in …

Background: The resistance to colistin and carbapenems in Klebsiella pneumoniae
infections have been associated with increased morbidity and mortality worldwide. A …