Recent advancement in understanding of Alzheimer's disease: Risk factors, subtypes, and drug targets and potential therapeutics

S Prabha, M Sajad, GM Hasan, A Islam… - Ageing Research …, 2024 - Elsevier
Alzheimer's disease (AD) is a significant neocortical degenerative disorder characterized by
the progressive loss of neurons and secondary alterations in white matter tracts …

Navigating the Maze of Alzheimer's Disease by Exploring BACE1: Discovery, Current Scenario, and Future Prospects

F Iram, M Shahid, J Ansari, GM Ashraf… - Ageing Research …, 2024 - Elsevier
Alzheimer's disease (AD) is a chronic neurological condition that has become a leading
cause of cognitive decline in elder individuals. Hardly any effective medication has been …

Exploring the promising potential of noscapine for cancer and neurodegenerative disease therapy through inhibition of integrin-linked kinase-1

MA Hakami, BS Alotaibi, SS Alkhalil, S Anwar… - International Journal of …, 2024 - Elsevier
Abstract Integrin-linked kinase (ILK), a β1-integrin cytoplasmic domain interacting protein,
supports multi-protein complex formation. ILK-1 is involved in neurodegenerative diseases …

[HTML][HTML] Pharmacological Features and Therapeutic Implications of Plumbagin in Cancer and Metabolic Disorders: A Narrative Review

B Sharma, C Dhiman, GM Hasan, A Shamsi… - Nutrients, 2024 - mdpi.com
Plumbagin (PLB) is a naphthoquinone extracted from Plumbago indica. In recent times,
there has been a growing body of evidence suggesting the potential importance of …

Genome-scale CRISPR-Cas9 screening in stem cells: theories, applications and challenges

H Zhou, P Ye, W Xiong, X Duan, S Jing, Y He… - Stem Cell Research & …, 2024 - Springer
Due to the rapid development of stem cell technology, there have been tremendous
advances in molecular biological and pathological research, cell therapy as well as …

Mesenchymal stem cell therapy for Alzheimer's disease: A novel therapeutic approach for neurodegenerative diseases

A Bhatt, H Bhardwaj, P Shrivastava - Neuroscience, 2024 - Elsevier
Alzheimer's disease (AD) is one of the most progressive and prevalent types of
neurodegenerative diseases in the aging population (aged> 65 years) and is considered a …

Analysis of Effect of Intensity of Aerobic Exercise on Cognitive and Motor Functions and Neurotrophic Factor Expression Patterns in an Alzheimer's Disease Rat Model

DY Lee, SC Im, NY Kang, K Kim - Journal of Personalized Medicine, 2023 - mdpi.com
The effect of aerobic exercise at different intensities on Alzheimer's disease (AD) still
remains unclear. We investigated the effect of aerobic exercise at different intensities on …

[PDF][PDF] MiR-502-3p/miR-501-3p as potential synaptic biomarker in Alzheimer's Disease: Analysis based on cerebrospinal fluid and neuropathology

D Devara, B Sharma, MM Torres, S Rodriguez… - 2024 - scholar.archive.org
MiRNAs are currently being studied for their biomarker potential in many diseases, including
Alzheimer's disease (AD). Here, we explored the biomarker potential of miR-502-3p/miR …

[图书][B] Tau Pathology in Alzheimer's Disease and Other Dementias–Translational Approach From in Vitro Autoradiography to in Vivo Pet Imaging

ML Malarte - 2024 - search.proquest.com
Tauopathies, including Alzheimer's disease (AD), corticobasal degeneration (CBD), and
progressive supranuclear palsy (PSP), are complex neurodegenerative disorders …

[PDF][PDF] Biochimica dell'Alzeimer: il ruolo della proteina Tau nella fisiopatologia della malattia

F RESTA - 2022 - unitesi.uniupo.it
Questo mio elaborato di tesi si propone di approfondire la malattia di Alzheimer, una
patologia neurodegenerativa caratterizzata da un progressivo declino delle funzioni …