During restricted time windows of postnatal life, called critical periods, neural circuits are
highly plastic and are shaped by environmental stimuli. In several mammalian brain areas …

Semaphorins, originally discovered as guidance cues for developing axons, are involved in
many processes that shape the nervous system during development, from neuronal …

Perineuronal nets (PNNs) are chondroitin-sulfate glycosaminoglycan (CS-GAG) containing
extracellular matrix structures that assemble around neurons involved in learning, memory …

As chemically specialized forms of the extracellular matrix in the central nervous system,
polyanionic perineuronal nets (PNs) contain diverse constituents, including chondroitin …

The perineuronal net (PNN) is a highly latticed extracellular matrix in the central nervous
system, which is composed of hyaluronic acid, proteoglycan, hyaluronan and proteoglycan …

Contextual triggers are significant factors contributing to relapse in substance use disorders
(SUD). Emerging evidence points to a critical role of extracellular matrix (ECM) molecules as …

The extracellular matrix (ECM) of the brain comprises unique glycan “sulfation codes” that
influence neurological function. Perineuronal nets (PNNs) are chondroitin sulfate …

Chondroitin sulfate (CS), dermatan sulfate (DS) and heparan sulfate (HS) are covalently
attached to specific core proteins to form proteoglycans in their biosynthetic pathways. They …

Fast-spiking parvalbumin interneurons are critical for the function of mature cortical inhibitory
circuits. Most of these neurons are enwrapped by a specialized extracellular matrix (ECM) …

Perineuronal nets (PNNs) are condensed extracellular matrix (ECM) structures found
throughout the central nervous system that regulate plasticity. They consist of a …