[HTML][HTML] Peering into avian influenza a (H5N8) for a framework towards pandemic preparedness
2014 marked the first emergence of avian influenza A (H5N8) in Jeonbuk Province, South
Korea, which then quickly spread worldwide. In the midst of the 2020–2021 H5N8 outbreak …
Korea, which then quickly spread worldwide. In the midst of the 2020–2021 H5N8 outbreak …
Molecular characteristics of repotrectinib that enable potent inhibition of TRK fusion proteins and resistant mutations
BW Murray, E Rogers, D Zhai, W Deng, X Chen… - Molecular cancer …, 2021 - AACR
NTRK chromosomal rearrangements yield oncogenic TRK fusion proteins that are sensitive
to TRK inhibitors (larotrectinib and entrectinib) but often mutate, limiting the durability of …
to TRK inhibitors (larotrectinib and entrectinib) but often mutate, limiting the durability of …
Sagacious epitope selection for vaccines, and both antibody-based therapeutics and diagnostics: tips from virology and oncology
The target of an antibody plays a significant role in the success of antibody-based
therapeutics and diagnostics, and vaccine development. This importance is focused on the …
therapeutics and diagnostics, and vaccine development. This importance is focused on the …
Control of cell proliferation by memories of mitosis
F Meitinger, H Belal, RL Davis, MB Martinez, AK Shiau… - Science, 2024 - science.org
Mitotic duration is tightly constrained, and extended mitosis is characteristic of problematic
cells prone to chromosome missegregation and genomic instability. We show here that …
cells prone to chromosome missegregation and genomic instability. We show here that …
[HTML][HTML] Evolution of increased positive charge on the SARS-CoV-2 spike protein may be adaptation to human transmission
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to evolve
and infect individuals. The exterior surface of the SARS-CoV-2 virion is dominated by the …
and infect individuals. The exterior surface of the SARS-CoV-2 virion is dominated by the …
[HTML][HTML] A comprehensive analysis of SARS-CoV-2 missense mutations indicates that all possible amino acid replacements in the viral proteins occurred within the …
The surveillance of COVID-19 pandemic has led to the determination of millions of genome
sequences of the SARS-CoV-2 virus, with the accumulation of a wealth of information never …
sequences of the SARS-CoV-2 virus, with the accumulation of a wealth of information never …
Improving the filtering of false positive single nucleotide variations by combining genomic features with quality metrics
KK Eren, E Çınar, HU Karakurt, A Özgür - Bioinformatics, 2023 - academic.oup.com
Motivation Technical errors in sequencing or bioinformatics steps and difficulties in
alignment at some genomic sites result in false positive (FP) variants. Filtering based on …
alignment at some genomic sites result in false positive (FP) variants. Filtering based on …
[HTML][HTML] A global analysis of conservative and non-conservative mutations in SARS-CoV-2 detected in the first year of the COVID-19 world-wide diffusion
The ability of SARS-CoV-2 to rapidly mutate represents a remarkable complicancy.
Quantitative evaluations of the effects that these mutations have on the virus …
Quantitative evaluations of the effects that these mutations have on the virus …
[HTML][HTML] Spontaneous mutations in HIV-1 gag, protease, RT p66 in the first replication cycle and how they appear: insights from an in vitro assay on mutation rates and …
While drug resistant mutations in HIV-1 are largely credited to its error prone HIV-1 RT, the
time point in the infection cycle that these mutations can arise and if they appear …
time point in the infection cycle that these mutations can arise and if they appear …
[HTML][HTML] Impact of the Types and Relative Quantities of IGHV Gene Mutations in Predicting Prognosis of Patients With Chronic Lymphocytic Leukemia
Patients with CLL with mutated IGHV genes (M-CLL) have better outcomes than patients
with unmutated IGHVs (U-CLL). Since U-CLL usually express immunoglobulins (IGs) that …
with unmutated IGHVs (U-CLL). Since U-CLL usually express immunoglobulins (IGs) that …