Over the past decade, the most significant, conceptual advances in the field of fluorination
were enabled most prominently by organo‐and transition‐metal catalysis. The most …

Fluorine has received great attention in all fields of science.“Small atom with a big ego” was
the title of the Symposium at the ACS meeting in San Francisco in 2000, where a number of …

Die wichtigsten konzeptionellen Fortschritt auf dem Gebiet der Fluorierungen der letzten
zehn Jahre wurden durch die Organo‐und Übergangsmetallkatalyse ermöglicht. Die …

Monofluoroalkenes are an important fluorinated class of compounds with applications in
medicinal chemistry, material sciences and organic chemistry. An overview of methods …

Histone deacetylases (HDACs) are enzymes pursued as drug targets in various cancers and
several non-oncological conditions, such as inflammation and neurodegenerative disorders …

The replacement of the amide bond in a peptide backbone is a promising strategy in
peptidomimetic drug research. Over the various amide bond surrogates, the fluoroolefin …

Amide groups are pervasive across the chemical space continuum, where their structural
and pharmacological importance, juxtaposed with the hydrolytic vulnerabilities, continues to …

Abstract gem‐Heteroatom‐substituted fluoroalkenes have received little attention despite
their great potential in medicinal chemistry or in fine chemistry. Indeed, due to the electronic …

The feasibility of the fluoro-olefin function as a peptidomimetic group in inhibitors for
dipeptidyl peptidase IV and II (DPP IV and DPP II) is investigated by evaluation of N …

The synthesis of fluorinated compounds as well as the use of these products as building
blocks for the preparation of complex molecules are fast growing research areas. Herein we …