Ischemic stroke generates an immune response that contributes to neuronal loss as well as
tissue repair. This is a complex process involving a range of cell types and effector …

Aging is associated with chronic systemic inflammation, which contributes to the
development of many age-related diseases, including vascular disease. The world's …

Rationale: The elderly experience profound systemic responses after stroke, which
contribute to higher mortality and more severe long-term disability. Recent studies have …

Hemorrhagic transformation (HT) is a common complication in patients with acute ischemic
stroke. It occurs when peripheral blood extravasates across a disrupted blood brain barrier …

Lipofuscin is an autofluorescent (AF) pigment formed by lipids and misfolded proteins, which
accumulates in postmitotic cells with advanced age. Here, we immunophenotyped microglia …

Ischaemic stroke involves the rapid onset of focal neurological dysfunction, most commonly
due to an arterial blockage in a specific region of the brain. Stroke is a leading cause of …

The microbiota-gut-brain-axis (MGBA) is a bidirectional communication network between gut
microbes and their host. Many environmental and host-related factors affect the gut …

Over the past millennia, life expectancy has drastically increased. While a mere 25 years
during Bronze and Iron ages, life expectancy in many European countries and in Japan is …

Rationale: Hemorrhagic complications represent a major limitation of intravenous
thrombolysis using tPA (tissue-type plasminogen activator) in patients with ischemic stroke …

Ischaemic stroke is a leading cause of disability and death for which no acute treatments
exist beyond recanalization. The development of novel therapies has been repeatedly …