Placental origins of chronic disease

GJ Burton, AL Fowden… - Physiological …, 2016 - journals.physiology.org
Epidemiological evidence links an individual's susceptibility to chronic disease in adult life to
events during their intrauterine phase of development. Biologically this should not be …

Maternal–fetal nutrient transport in pregnancy pathologies: the role of the placenta

KE Brett, ZM Ferraro, J Yockell-Lelievre… - International journal of …, 2014 - mdpi.com
Appropriate in utero growth is essential for offspring development and is a critical contributor
to long-term health. Fetal growth is largely dictated by the availability of nutrients in maternal …

The programming power of the placenta

AN Sferruzzi-Perri, EJ Camm - Frontiers in physiology, 2016 - frontiersin.org
Size at birth is a critical determinant of life expectancy, and is dependent primarily on the
placental supply of nutrients. However, the placenta is not just a passive organ for the …

Placental phenotype and the insulin‐like growth factors: resource allocation to fetal growth

AN Sferruzzi‐Perri, I Sandovici… - The Journal of …, 2017 - Wiley Online Library
The placenta is the main determinant of fetal growth and development in utero. It supplies all
the nutrients and oxygen required for fetal growth and secretes hormones that facilitate …

Adiponectin supplementation in pregnant mice prevents the adverse effects of maternal obesity on placental function and fetal growth

ILMH Aye, FJ Rosario, TL Powell… - Proceedings of the …, 2015 - National Acad Sciences
Mothers with obesity or gestational diabetes mellitus have low circulating levels of
adiponectin (ADN) and frequently deliver large babies with increased fat mass, who are …

Molecular pathways disrupted by gestational diabetes mellitus

C Nguyen-Ngo, N Jayabalan… - Journal of molecular …, 2019 - jme.bioscientifica.com
Gestational diabetes mellitus (GDM) imposes serious short-and long-term health problems
for mother and baby. An effective therapeutic that can reduce the incidence of GDM and …

The role of placental nutrient sensing in maternal-fetal resource allocation

P Díaz, TL Powell, T Jansson - Biology of reproduction, 2014 - academic.oup.com
The placenta mediates maternal-fetal exchange and has historically been regarded as a
passive conduit for nutrients. However, emerging evidence suggests that the placenta …

Regulation of placental amino acid transport and fetal growth

OR Vaughan, FJ Rosario, TL Powell… - Progress in molecular …, 2017 - Elsevier
The fetus requires amino acids for the processes of protein synthesis, carbon accretion,
oxidative metabolism, and biosynthesis, which ultimately determine growth rate in utero. The …

Placental adaptations supporting fetal growth during normal and adverse gestational environments

AN Sferruzzi‐Perri, J Lopez‐Tello… - Experimental …, 2023 - Wiley Online Library
The placenta is vital for mammalian development and a key determinant of life‐long health.
It is the interface between the mother and fetus and is responsible for transporting the …

Milk—A nutrient system of mammalian evolution promoting mTORC1-dependent translation

BC Melnik - International journal of molecular sciences, 2015 - mdpi.com
Based on own translational research of the biochemical and hormonal effects of cow's milk
consumption in humans, this review presents milk as a signaling system of mammalian …