Brain endocannabinoid (eCB) signalling influences the motivation for natural rewards (such
as palatable food, sexual activity and social interaction) and modulates the rewarding effects …

The endogenous cannabinoid system is an important regulatory system involved in
physiological homeostasis. Endocannabinoid signaling is known to modulate neural …

Introduction Cannabidiol (CBD) is a phytocannabinoid found in the Cannabis plant. CBD
has received significant medical attention in relation to its anticonvulsant, anxiolytic, and …

Cannabidiol is a non‐psychotomimetic constituent of C annabis sativa, which induces
central effects in rodents. It has been shown that cannabidiol attenuates cue‐induced …

Cannabinoid receptor 1 (CB1R) has been one of the major targets in medication
development for treating substance use disorders (SUDs). Early studies indicated that …

Substance use disorder (SUD) is a major public health crisis worldwide, and effective
treatment options are limited. During the past 2 decades, researchers have investigated the …

Abstract Δ9-tetrahydrocannabinol (Δ9-THC), the main psychoactive ingredient of marijuana,
has led to equivocal results when tested with the intracranial self-stimulation (ICSS) …

Over the last decades, the endocannabinoid system has been implicated in a large variety of
functions, including a crucial modulation of brain-reward circuits and the regulation of …

Rationale Whereas cannabinoid CB 1 receptors have long been known to contribute to the
rewarding effects and dependence liability of many drugs of abuse, recent studies have …

Nicotine, the main psychoactive component of tobacco, and (−)− Δ 9-tetrahydrocannabinol
(THC), the main psychoactive ingredient in cannabis, play major roles in tobacco and …