A comprehensive review of microneedles: Types, materials, processes, characterizations and applications

FK Aldawood, A Andar, S Desai - Polymers, 2021 - mdpi.com
Drug delivery through the skin offers many advantages such as avoidance of hepatic first-
pass metabolism, maintenance of steady plasma concentration, safety, and compliance over …

Microneedles in drug delivery: progress and challenges

M Avcil, A Çelik - Micromachines, 2021 - mdpi.com
In recent years, an innovative transdermal delivery technology has attracted great interest for
its ability to distribute therapeutics and cosmeceuticals for several applications, including …

The safety, immunogenicity, and acceptability of inactivated influenza vaccine delivered by microneedle patch (TIV-MNP 2015): a randomised, partly blinded, placebo …

NG Rouphael, M Paine, R Mosley, S Henry… - The Lancet, 2017 - thelancet.com
Background Microneedle patches provide an alternative to conventional needle-and-syringe
immunisation, and potentially offer improved immunogenicity, simplicity, cost-effectiveness …

Engineering microneedle patches for vaccination and drug delivery to skin

MR Prausnitz - Annual review of chemical and biomolecular …, 2017 - annualreviews.org
Microneedle patches (MNPs) contain arrays of solid needles measuring hundreds of
microns in length that deliver drugs and vaccines into skin in a painless, easy-to-use …

Microneedle-mediated transdermal delivery of biopharmaceuticals

HX Nguyen, CN Nguyen - Pharmaceutics, 2023 - mdpi.com
Transdermal delivery provides numerous benefits over conventional routes of
administration. However, this strategy is generally limited to a few molecules with specific …

Microneedle patches for vaccination in developing countries

J Arya, MR Prausnitz - Journal of Controlled Release, 2016 - Elsevier
Millions of people die of infectious diseases each year, mostly in developing countries,
which could largely be prevented by the use of vaccines. While immunization rates have …

Dissolvable microneedle patches to enable increased access to vaccines against SARS-CoV-2 and future pandemic outbreaks

J O'Shea, MR Prausnitz, N Rouphael - Vaccines, 2021 - mdpi.com
Vaccines are an essential component of pandemic preparedness but can be limited due to
challenges in production and logistical implementation. While vaccine candidates were …

Technology update: Dissolvable microneedle patches for vaccine delivery

AM Rodgers, AS Cordeiro… - … Devices: Evidence and …, 2019 - Taylor & Francis
Despite vaccination representing one of the greatest advances of modern preventative
medicine, there remain significant challenges in vaccine distribution, delivery and …

Polymeric nanoparticle-based vaccine adjuvants and delivery vehicles

EA Grego, AC Siddoway, M Uz, L Liu… - … for Rational Vaccine …, 2020 - Springer
As vaccine formulations have progressed from including live or attenuated strains of
pathogenic components for enhanced safety, developing new adjuvants to more effectively …

Recent advances in combination of microneedles and nanomedicines for lymphatic targeted drug delivery

AD Permana, F Nainu, K Moffatt… - Wiley …, 2021 - Wiley Online Library
Numerous diseases have been reported to affect the lymphatic system. As such, several
strategies have been developed to deliver chemotherapeutics to this specific network of …