The basic vertebrate body plan of the zebrafish embryo is established in the first 10 hours of
development. This period is characterized by the formation of the anterior-posterior and …

Motor neuron diseases (MNDs) are an etiologically heterogeneous group of disorders of
neurodegenerative origin, which result in degeneration of lower (LMNs) and/or upper motor …

Statins inhibit HMG-CoA reductase, a key enzyme in cholesterol synthesis, and are widely
used to treat hypercholesterolemia. These drugs can lead to a number of side effects in …

Genetic screens in zebrafish (Danio rerio) have identified mutations that define the roles of
hundreds of essential vertebrate genes. Genetic maps can link mutant phenotype with gene …

Abstract Synaptotagmin 1 and 2 (syt 1, syt 2) are synaptic vesicle‐associated membrane
proteins that act as calcium sensors for fast neurotransmitter release from presynaptic nerve …

Axonal morphology is a critical determinant of neuronal connectivity, and perturbation of the
rate or extent of axonal growth during development has been linked to neurobehavioral …

Statins are widely used to treat hypercholesterolemia but can lead to a number of side
effects in muscle, including rhabdomyolysis. Our recent findings implicated the induction of …

Small freshwater fish models, especially zebrafish, offer advantages over traditional rodent
models, including low maintenance and husbandry costs, high fecundity, genetic diversity …

Through the direct analysis of cell behaviors, we address the mechanisms underlying
anterior neural tube morphogenesis in the zebrafish and the role of the cell adhesion …

Genetic screens for synaptogenesis mutants have been performed in many organisms, but
few if any have simultaneously screened for defects in pre-and postsynaptic specializations …