Failure of cartilage regeneration: emerging hypotheses and related therapeutic strategies

S Muthu, JV Korpershoek, EJ Novais… - Nature Reviews …, 2023 - nature.com
Osteoarthritis (OA) is a disabling condition that affects billions of people worldwide and
places a considerable burden on patients and on society owing to its prevalence and …

Osteoarthritis: toward a comprehensive understanding of pathological mechanism

DI Chen, J Shen, W Zhao, T Wang, L Han, JL Hamilton… - Bone research, 2017 - nature.com
Osteoarthritis (OA) is the most common degenerative joint disease and a major cause of
pain and disability in adult individuals. The etiology of OA includes joint injury, obesity …

[HTML][HTML] Osteoarthritis: a disease of the joint as an organ

RF Loeser, SR Goldring, CR Scanzello… - Arthritis and …, 2012 - ncbi.nlm.nih.gov
Osteoarthritis (OA) is the most common form of arthritis and a major cause of pain and
disability in older adults (1). Often OA is referred to as degenerative joint disease “(DJD)” …

Knee osteoarthritis: Current status and research progress in treatment

R Geng, J Li, C Yu, C Zhang… - Experimental and …, 2023 - spandidos-publications.com
Knee osteoarthritis (KOA) is a common chronic articular disease worldwide. It is also the
most common form of OA and is characterized by high morbidity and disability rates. With the …

Spectral photon-counting computed tomography: a review on technical principles and clinical applications

M Tortora, L Gemini, I D'Iglio, L Ugga, G Spadarella… - Journal of …, 2022 - mdpi.com
Photon-counting computed tomography (CT) is a technology that has attracted increasing
interest in recent years since, thanks to new-generation detectors, it holds the promise to …

[HTML][HTML] Knee extensor muscle weakness is a risk factor for development of knee osteoarthritis. A systematic review and meta-analysis

BE Øiestad, CB Juhl, I Eitzen, JB Thorlund - Osteoarthritis and cartilage, 2015 - Elsevier
The objective of this study was to perform a systematic review and meta-analysis on the
association between knee extensor muscle weakness and the risk of developing knee …

Role of inflammation in the pathogenesis of osteoarthritis: latest findings and interpretations

J Sokolove, CM Lepus - Therapeutic advances in …, 2013 - journals.sagepub.com
Osteoarthritis (OA) has traditionally been classified as a noninflammatory arthritis; however,
the dichotomy between inflammatory and degenerative arthritis is becoming less clear with …

Chondrogenesis, chondrocyte differentiation, and articular cartilage metabolism in health and osteoarthritis

MB Goldring - Therapeutic advances in musculoskeletal …, 2012 - journals.sagepub.com
Chondrogenesis occurs as a result of mesenchymal cell condensation and
chondroprogenitor cell differentiation. Following chondrogenesis, the chondrocytes remain …

The long-term consequence of anterior cruciate ligament and meniscus injuries: osteoarthritis

LS Lohmander, PM Englund… - The American journal …, 2007 - journals.sagepub.com
The objectives of this study are to review the long-term consequences of injuries to the
anterior cruciate ligament and menisci, the pathogenic mechanisms, and the causes of the …

[HTML][HTML] Baseline knee adduction and flexion moments during walking are both associated with 5 year cartilage changes in patients with medial knee osteoarthritis

EF Chehab, J Favre, JC Erhart-Hledik… - Osteoarthritis and …, 2014 - Elsevier
Objective To test the hypothesis that knee cartilage changes over 5 years are associated
with baseline peak knee adduction moment (KAM) and peak knee flexion moment (KFM) …