Natural killer (NK) cells can swiftly kill multiple adjacent cells if these show surface markers
associated with oncogenic transformation. This property, which is unique among immune …

Natural killer (NK) cells are innate lymphocytes that provide critical host defense against
pathogens and cancer. Originally heralded for their early and rapid effector activity, NK cells …

The pathogenesis of severe COVID-19 reflects an inefficient immune reaction to SARS-CoV-
2. Here we analyze, at the single cell level, plasmablasts egressed into the blood to study …

Although the aetiology of systemic lupus erythematosus (SLE) is unclear, dysregulated B
cell responses have been implicated. Here we show that an unusual CD11chiT-bet+ B cell …

The common cytokine receptor γ chain, γ c, is a component of the receptors for interleukin-2
(IL-2), IL-4, IL-7, IL-9, IL-15, and IL-21. Mutation of the gene encoding γ c results in X-linked …

Cytokines are a class of potent immunoregulatory proteins that are secreted in response to
various stimuli and act locally to regulate many aspects of human physiology and disease …

In celebration of the 50th anniversary of the discovery of B cells, I take a look back at the
history of T cell help to B cells, which was discovered 47 years ago. In addition, I summarize …

Intercellular communication mediated by cytokines is the main mechanism by which cells of
the immune system talk to each other. Many aspects of cytokine signalling in the immune …

Natural killer (NK) cells are effective in combating infections and tumors and as such are
tempting for adoptive transfer therapy. However, they are not homogeneous but can be …

Natural killer (NK) cells play critical roles in host immunity against cancer. In response,
cancers develop mechanisms to escape NK cell attack or induce defective NK cells. Current …