Pseudomonas aeruginosa: pathogenesis, virulence factors, antibiotic resistance, interaction with host, technology advances and emerging therapeutics

S Qin, W Xiao, C Zhou, Q Pu, X Deng, L Lan… - Signal transduction and …, 2022 - nature.com
Pseudomonas aeruginosa (P. aeruginosa) is a Gram-negative opportunistic pathogen that
infects patients with cystic fibrosis, burn wounds, immunodeficiency, chronic obstructive …

Targeting the holy triangle of quorum sensing, biofilm formation, and antibiotic resistance in pathogenic bacteria

RV Sionov, D Steinberg - Microorganisms, 2022 - mdpi.com
Chronic and recurrent bacterial infections are frequently associated with the formation of
biofilms on biotic or abiotic materials that are composed of mono-or multi-species cultures of …

Roles of Two-Component Systems in Pseudomonas aeruginosa Virulence

M Sultan, R Arya, KK Kim - International journal of molecular sciences, 2021 - mdpi.com
Pseudomonas aeruginosa is an opportunistic pathogen that synthesizes and secretes a
wide range of virulence factors. P. aeruginosa poses a potential threat to human health …

Cyclic di-GMP: the first 25 years of a universal bacterial second messenger

U Römling, MY Galperin… - … and Molecular Biology …, 2013 - Am Soc Microbiol
Twenty-five years have passed since the discovery of cyclic dimeric (3′→ 5′) GMP (cyclic
di-GMP or c-di-GMP). From the relative obscurity of an allosteric activator of a bacterial …

Escaping the biofilm in more than one way: desorption, detachment or dispersion

OE Petrova, K Sauer - Current opinion in microbiology, 2016 - Elsevier
Highlights•At least three types of “escapes” or ways for bacteria to leave the biofilm are
known.•Types of escapes are referred to as desorption, detachment, and …

A dynamic and intricate regulatory network determines Pseudomonas aeruginosa virulence

D Balasubramanian, L Schneper, H Kumari… - Nucleic acids …, 2013 - academic.oup.com
Pseudomonas aeruginosa is a metabolically versatile bacterium that is found in a wide
range of biotic and abiotic habitats. It is a major human opportunistic pathogen causing …

How bacteria recognise and respond to surface contact

TEP Kimkes, M Heinemann - FEMS microbiology reviews, 2020 - academic.oup.com
Bacterial biofilms can cause medical problems and issues in technical systems. While a
large body of knowledge exists on the phenotypes of planktonic and of sessile cells in …

Sticky situations: key components that control bacterial surface attachment

OE Petrova, K Sauer - Journal of bacteriology, 2012 - Am Soc Microbiol
The formation of bacterial biofilms is initiated by cells transitioning from the free-swimming
mode of growth to a surface. This review is aimed at highlighting the common themes that …

Pseudomonas aeruginosa biofilm infections: community structure, antimicrobial tolerance and immune response

M Rybtke, LD Hultqvist, M Givskov… - Journal of molecular …, 2015 - Elsevier
Studies of biopsies from infectious sites, explanted tissue and medical devises have
provided evidence that biofilms are the underlying cause of a variety of tissue-associated …

An update on Pseudomonas aeruginosa biofilm formation, tolerance, and dispersal

M Harmsen, L Yang, SJ Pamp… - FEMS Immunology & …, 2010 - academic.oup.com
We review the recent advances in the understanding of the Pseudomonas aeruginosa
biofilm lifestyle from studies using in vitro laboratory setups such as flow chambers and …