From transcription, to transport, storage, and translation, RNA depends on association with
different RNA‐binding proteins (RBPs). Methods based on next‐generation sequencing and …

Multiple human diseases are associated with a liquid-to-solid phase transition resulting in
the formation of amyloid fibers or protein aggregates. Here, we present an alternative …

The combination of high-throughput sequencing and in vivo crosslinking approaches leads
to the progressive uncovering of the complex interdependence between cellular …

A progressive loss of protein homeostasis is characteristic of aging and a driver of
neurodegeneration. To investigate this process quantitatively, we characterized proteome …

The long non-coding RNA Xist induces heterochromatinization of the X chromosome by
recruiting repressive protein complexes to chromatin. Here we gather evidence, from the …

Cells must coordinate the activation of thousands of replication origins dispersed throughout
their genome. Active transcription is known to favor the formation of mammalian origins …

Motivation: RNA binding proteins (RBPs) play important roles in post-transcriptional control
of gene expression, including splicing, transport, polyadenylation and RNA stability. To …

Motivation: Recent technological advances revealed that an unexpected large number of
proteins interact with transcripts even if the RNA-binding domains are not annotated. We …

Proteins and RNAs assemble in membrane-less organelles that organize intracellular
spaces and regulate biochemical reactions. The ability of proteins and RNAs to form …

Gene expression can be modulated by epigenetic mechanisms, including chromatin
modifications and small regulatory RNAs. These pathways are unevenly distributed within a …