Stachydrine, a pyrrole alkaloid with promising therapeutic potential against metabolic syndrome and associated organ dysfunction

SA Ahmed, JC Borah, P Manna - RSC Medicinal Chemistry, 2024 - pubs.rsc.org
Metabolic syndrome is a multifaceted condition marked by interconnected risk factors,
significantly increasing the risk of serious diseases like cardiovascular disease, type 2 …

Syringic acid improves cyclophosphamide-induced immunosuppression in a mouse model

KS Mughal, M Ikram, Z Uddin, A Rashid… - Biochemical and …, 2024 - Elsevier
Syringic acid (SA), a naturally occurring phenolic substance present in many edible plants
and fruits, has been shown to have potential in immunoenhancement applications. In this …

An Evaluation of the Novel Biological Properties of Diterpenes Isolated from Plectranthus ornatus Codd. In Vitro and In Silico

P Sitarek, T Kowalczyk, E Synowiec… - Cells, 2022 - mdpi.com
Plectranthus ornatus Codd, the genus Plectranthus of the Lamiaceae family, has been used
as traditional medicine in Africa, India and Australia. Pharmacological studies show the use …

Optimization of the extract from flower of Citrus aurantium L. var. amara Engl. and its inhibition of lipid accumulation

WF Cai, MM Yan, Z Wang, MP Jiang… - Journal of Food …, 2022 - Wiley Online Library
Flower of Citrus aurantium L. var. amara Engl.(CAVA) has been confirmed to have promising
anti‐obesity effects. However, the regulation of alkaloid extracts from flower of CAVA (Al) on …

Specific blood metabolite associations with Gout: a Mendelian randomization study

H Zeng, J Lai, Z Liu, W Liu, Y Zhang - European Journal of Clinical …, 2024 - nature.com
Objective Gout, common metabolic disorders, have poorly understood links with blood
metabolites. Exploring these relationships could enhance clinical prevention and treatment …

Phytochemical investigation, structural elucidation, in silico study and anti-psoriatic activity of potent bioactive from Betula utilis

P Biswasroy, D Pradhan, DK Sahu, V Rai… - Journal of …, 2023 - Taylor & Francis
Psoriasis is a chronic autoimmune pathological condition characterized by hyperactivation
of proinflammatory cytokines (IL-6, TNF-α, IL-17, IL-23, etc.). Severe drug-associated …

Neuroinflammatory response on a newly combinatorial cell–cell interaction chip

Y Zhao, X Lv, Y Chen, C Zhang, D Zhou… - Biomaterials Science, 2024 - pubs.rsc.org
Neuroinflammation is a common feature in various neurological disorders. Understanding
neuroinflammation and neuro-immune interactions is of significant importance. However, the …

Exploring the potential therapeutic benefits of 7-methoxy coumarin for neuropathy pain: an in vivo, in vitro, and in silico approach

BV Cheriyan, J Shanmugasundaram… - Molecular Biology …, 2024 - Springer
Back ground 7-Methoxycoumarin (7-MC) is well recognized for its anti-inflammatory and anti-
nociceptive actions. Its capacity to lessen neuropathic pain hasn't been documented yet …

[HTML][HTML] Computational exploration of single-nucleotide polymorphisms in the human hRAS gene: Implications and insights

S Dakshitha, V Suresh, E Dilipan - Cureus, 2024 - ncbi.nlm.nih.gov
Background A group of genes called oncogenes includes the Harvey rat sarcoma virus
(hRAS) gene. Along with hRAS, Kirsten rat sarcoma viral oncogene homolog (kRAS) and …

[HTML][HTML] Molecular Docking of Seaweed-Derived Drug Fucoxanthin Against the Monkeypox Virus

R Nikitha, KLG Afeeza, V Suresh, E Dilipan - Cureus, 2024 - ncbi.nlm.nih.gov
Background The monkeypox virus (MPXV) is classified as a zoonotic virus of the Poxviridae
family, resulting from the MPXV strain of the Orthopoxvirus genus. Seaweeds, or marine …