Natural killer (NK) cells are effector cells of the innate immune system and are important in
the control of viral infections. Their relevance is reflected by the multiple mechanisms …

ABSTRACT NK cell effector function is regulated by a range of activating and inhibitory
receptors, and many of their known ligands are MHC class I molecules. Human NK …

Natural killer (NK) cells mediate innate defense against viral infections, but the mechanisms
in place to access their functions as needed during diverse challenges while limiting …

The innate immune system is the first line of defence in response to pathogen infection.
Natural killer (NK) cells perform a vital role in this response with the ability to directly kill …

Increased evidence of cross-talk between NK cells and other immune cells has enhanced
the possibilities of exploiting the interplay between the activation and inhibition of NK cells …

Background To date, drug response genes have not proved as useful in clinical practice as
was anticipated at the start of the genomic era. An exception is in the treatment of chronic …

In 1989, hepatitis C virus (HCV) was first identified as the infectious agent responsible for
human non-A, non-B hepatitis. Two decades later, HCV remains a global public health …

HCV infection is a global health problem that affects 170 million people worldwide. The
severity of the disease varies from asymptomatic chronic infection to cirrhosis and …

Specific NK cell killer inhibitory receptor (KIR): HLA haplotype combinations have been
associated with successful clearance of acute and chronic HCV infection. Whether an …

Introduction Murine hepatic NK cells exhibit adaptive features, with liver‐specific adhesion
molecules CXCR6 and CD49a acting as surface markers. Methods We investigated human …