[HTML][HTML] Regulation of intestinal barrier function by microbial metabolites

S Ghosh, CS Whitley, B Haribabu, VR Jala - Cellular and molecular …, 2021 - Elsevier
The human gastrointestinal tract (GI) harbors a diverse population of microbial life that
continually shapes host pathophysiological responses. Despite readily available abundant …

[HTML][HTML] Interactions between gut microbiota and berberine, a necessary procedure to understand the mechanisms of berberine

H Cheng, J Liu, Y Tan, W Feng, C Peng - Journal of pharmaceutical …, 2022 - Elsevier
Berberine (BBR), an isoquinoline alkaloid, has been found in many plants, such as Coptis
chinensis Franch and Phellodendron chinense Schneid. Although BBR has a wide spectrum …

Oral colon-targeted mucoadhesive micelles with enzyme-responsive controlled release of curcumin for ulcerative colitis therapy

C Zhang, J Li, M Xiao, D Wang, Y Qu, L Zou… - Chinese Chemical …, 2022 - Elsevier
Although multitudinous nanoscale drug-delivery systems (DDSs) have been recommended
to improve anti-ulcerative colitis (UC) outcomes, to enhance the mucoadhesion of …

Anti‐inflammatory effect of Rhein on ulcerative colitis via inhibiting PI3K/Akt/mTOR signaling pathway and regulating gut microbiota

L Dong, H Du, M Zhang, H Xu, X Pu… - Phytotherapy …, 2022 - Wiley Online Library
This study aimed to analyze the therapeutic effect of Rhein on ulcerative colitis (UC) in mice
and its possible mechanism. LPS‐induced UC cell model and DSS‐induced UC mouse …

The triangular relationship between traditional Chinese medicines, intestinal flora, and colorectal cancer

Y Zou, S Wang, H Zhang, Y Gu, H Chen… - Medicinal Research …, 2024 - Wiley Online Library
Over the past decade, colorectal cancer has reported a higher incidence in younger adults
and a lower mortality rate. Recently, the influence of the intestinal flora in the initiation …

Phytochemicals and regulation of NF-kB in inflammatory bowel diseases: an overview of in vitro and in vivo effects

LF Laurindo, ARO Santos, ACA Carvalho, MD Bechara… - Metabolites, 2023 - mdpi.com
Inflammatory bowel diseases (IBD) are chronic relapsing idiopathic inflammatory conditions
affecting the gastrointestinal tract. They are mainly represented by two forms, ulcerative …

Berberine: a review of its pharmacokinetics properties and therapeutic potentials in diverse vascular diseases

X Ai, P Yu, L Peng, L Luo, J Liu, S Li, X Lai… - Frontiers in …, 2021 - frontiersin.org
Traditional Chinese medicine plays a significant role in the treatment of various diseases
and has attracted increasing attention for clinical applications. Vascular diseases affecting …

Thyme (Thymus vulgaris L.) polyphenols ameliorate DSS-induced ulcerative colitis of mice by mitigating intestinal barrier damage, regulating gut microbiota, and …

Z Zhou, W He, H Tian, P Zhan, J Liu - Food & function, 2023 - pubs.rsc.org
Thyme (Thymus vulgaris L.) is an important medicinal and edible homologous plant, and the
composition and bioactivity of its polyphenol extracts have attracted widespread attention …

Potential roles of gut microbes in biotransformation of natural products: An overview

Y Zhao, X Zhong, J Yan, C Sun, X Zhao… - Frontiers in …, 2022 - frontiersin.org
Natural products have been extensively applied in clinical practice, characterized by multi-
component and multi-target, many pharmacodynamic substances, complex action …

Cepharanthine ameliorates dextran sulphate sodium‐induced colitis through modulating gut microbiota

HG Wang, MN Zhang, X Wen, L He… - Microbial …, 2022 - Wiley Online Library
Cepharanthine (CEP) is an active alkaloid isolated from Stephania Cepharantha Hayata. It
is reported that the anti‐inflammatory properties of CEP could be employed to treat a variety …