The omega-3 hydroxy fatty acid 7(S)-HDHA is a high-affinity PPARα ligand that regulates brain neuronal morphology

J Liu, C Sahin, S Ahmad, L Magomedova, M Zhang… - Science …, 2022 - science.org
The nuclear receptor peroxisome proliferator-activated receptor alpha (PPARα) is emerging
as an important target in the brain for the treatment or prevention of cognitive disorders. The …

Comprehensive utilization of Hainan cashew nut shell: Process optimization of cashew nut shell liquid extraction and cardanol refinement by catalytic transfer …

H Wu, Q Li, H Yu, M Gu, Y Wang, C Xu… - Industrial Crops and …, 2023 - Elsevier
In this work, an eco-friendly approach to the extraction of cashew nut shell liquid (CNSL) and
the refinement of cardanol were explored for the first time using cashew nut produced in …

Engineering a dysbiotic biofilm model for testing root caries interventions through microbial modulation

N Dame‐Teixeira, R El-Gendy, AS de Oliveira… - Microbiome, 2024 - Springer
Background This study aimed to engineer and optimise a dysbiotic biofilm model to develop
in vitro root caries for investigating microbial modulation strategies. The model involved …

Benign-by-Design SAHA Analogues for Human and Animal Vector-Borne Parasitic Diseases

M Rossi, B Martinengo, E Diamanti… - ACS Medicinal …, 2024 - ACS Publications
The search for new drugs fulfilling One Health and Green Chemistry requirements is an
urgent call. Here, for the first time, we envisaged developing SAHA analogues by starting …

A novel fatty acid mimetic with pan-PPAR partial agonist activity inhibits diet-induced obesity and metabolic dysfunction-associated steatotic liver disease

C Sahin, JR Melanson, F Le Billan, L Magomedova… - Molecular …, 2024 - Elsevier
Objective The prevalence of metabolic diseases is increasing globally at an alarming rate;
thus, it is essential that effective, accessible, low-cost therapeutics are developed …

Isolation of Cardanol Fractions from Cashew Nutshell Liquid (CNSL): A Sustainable Approach

B Bhatia, N Amarnath, SK Rastogi, B Lochab - Sustainable Chemistry, 2024 - mdpi.com
Exploring sustainable approaches to replace petroleum-based chemicals is an ongoing
challenge in reducing the carbon footprint. Due to the complexity and percentage variation …

Valorizing constituents of cashew nut shell liquid toward the sustainable development of new drugs against chagas disease

LF Nunes Lemes, GE Magoulas… - ACS Infectious …, 2023 - ACS Publications
Six new ether phospholipid analogues encompassing constituents from cashew nut shell
liquid as the lipid portion were synthesized in an effort to valorize byproducts of the cashew …

[HTML][HTML] Combinatory Effect of Pequi Oil (Caryocar brasiliense)-Based Nanoemulsions Associated to Docetaxel and Anacardic Acid (Anacardium occidentale) in …

AS Ombredane, NO Martins, GMV de Souza… - Pharmaceutics, 2024 - mdpi.com
Combination therapy integrated with nanotechnology offers a promising alternative for
breast cancer treatment. The inclusion of pequi oil, anacardic acid (AA), and docetaxel …

Sustainable multifunctional phenolic lipids as potential therapeutics in Dentistry

N Dame-Teixeira, R El-Gendy, I Monici Silva… - Scientific Reports, 2022 - nature.com
Phenolic lipids components of the cashew nutshell liquid (CNSL) have molecular structures
capable of chemical signalling that regulate gene expression, metabolism and inflammation …

Effects of Cardanol-Based Phospholipid Analogs on Trichomonas vaginalis

TG de Souza, B de Lucena Costa, CA Holanda… - Experimental …, 2024 - Elsevier
Trichomonas vaginalis is a protist parasite of the urogenital tract, responsible for human
trichomoniasis, an infection sexually transmitted that affects approximately 156 million …