Spirooxindoles: Promising scaffolds for anticancer agents
The search for novel anticancer agents with more selectivity and lower toxicity continues to
be an area of intensive investigation. The unique structural features of spirooxindoles …
be an area of intensive investigation. The unique structural features of spirooxindoles …
[HTML][HTML] Pyrimidine: a review on anticancer activity with key emphasis on SAR
A Mahapatra, T Prasad, T Sharma - Future journal of pharmaceutical …, 2021 - Springer
Background Cancer is a global health challenge, it impacts the quality of life and its
treatment is associated with several side effects. Resistance of the cancer cells to the …
treatment is associated with several side effects. Resistance of the cancer cells to the …
Current status on development of steroids as anticancer agents
A Gupta, BS Kumar, AS Negi - The Journal of steroid biochemistry and …, 2013 - Elsevier
Steroids are important biodynamic agents. Their affinities for various nuclear receptors have
been an interesting feature to utilize them for drug development particularly for receptor …
been an interesting feature to utilize them for drug development particularly for receptor …
Synthetic chemistry of pyrimidines and fused pyrimidines: A review
S Mohana Roopan, R Sompalle - Synthetic Communications, 2016 - Taylor & Francis
This review is an attempt to compile the literature of various synthetic procedures of
pyrimidine analogs. Pyrimidine and its fused pyrimidine derivatives are a class of …
pyrimidine analogs. Pyrimidine and its fused pyrimidine derivatives are a class of …
Auspicious role of the steroidal heterocyclic derivatives as a platform for anti-cancer drugs
Steroids are polycyclic compounds that have a wide range of biological activities. They are
bio-synthesized from cholesterol through a series of enzyme-mediated transformations, so …
bio-synthesized from cholesterol through a series of enzyme-mediated transformations, so …
Construction of biologically important biaryl scaffolds through direct C–H bond activation: advances and prospects
Biaryl scaffolds are prevalent in natural products and drug molecules, and biaryl-containing
compounds have been shown to exhibit diverse and interesting biological activities. To date …
compounds have been shown to exhibit diverse and interesting biological activities. To date …
A comprehensive review of N-heterocycles as cytotoxic agents
D Kumar, S Kumar Jain - Current Medicinal Chemistry, 2016 - ingentaconnect.com
Scientific community is striving to understand the role of heterocycles and fused
heterocycles in drug discovery programme due to its impact on multi-drug resistance (MDR) …
heterocycles in drug discovery programme due to its impact on multi-drug resistance (MDR) …
Biological activities of [1,2,4]triazolo[1,5-a]pyrimidines and analogs
S Pinheiro, EMC Pinheiro, EMF Muri… - Medicinal Chemistry …, 2020 - Springer
Abstract The [1, 2, 4] triazolo [1, 5-a] pyrimidines (TPs) comprise an important class of non-
naturally occurring small molecules that aroused the interest of researches. This scaffold is …
naturally occurring small molecules that aroused the interest of researches. This scaffold is …
Construction of a Pyrimidine Framework through [3 + 2 + 1] Annulation of Amidines, Ketones, and N,N-Dimethylaminoethanol as One Carbon Donor
Z Qin, Y Ma, F Li - The Journal of Organic Chemistry, 2021 - ACS Publications
An efficient, facile, and eco-friendly synthesis of pyrimidine derivatives has been developed.
It involves a [3+ 2+ 1] three-component annulation of amidines, ketones, and one carbon …
It involves a [3+ 2+ 1] three-component annulation of amidines, ketones, and one carbon …
Efficient synthesis of new antiproliferative steroidal hybrids using the molecular hybridization approach
A series of steroidal hybrids with different terminal bioactive scaffolds were synthesized
using the molecular hybridization approach and further evaluated for their antiproliferative …
using the molecular hybridization approach and further evaluated for their antiproliferative …