Advances in research on type 2 diabetes mellitus targets and therapeutic agents

J Su, Y Luo, S Hu, L Tang, S Ouyang - International Journal of Molecular …, 2023 - mdpi.com
Diabetes mellitus is a chronic multifaceted disease with multiple potential complications, the
treatment of which can only delay and prolong the terminal stage of the disease, ie, type 2 …

The role of ChREBP in carbohydrate sensing and NAFLD development

M Régnier, T Carbinatti, L Parlati… - Nature Reviews …, 2023 - nature.com
Excessive sugar consumption and defective glucose sensing by hepatocytes contribute to
the development of metabolic diseases including type 2 diabetes mellitus (T2DM) and …

[HTML][HTML] T3 and glucose increase expression of phosphoenolpyruvate carboxykinase (PCK1) leading to increased β-cell proliferation

LS Katz, C Argmann, L Lambertini, DK Scott - Molecular Metabolism, 2022 - Elsevier
Objectives Thyroid hormone (T3) and high glucose concentrations are critical components of
β-cell maturation and function. In the present study, we asked whether T3 and glucose …

[HTML][HTML] Targeting β-cell plasticity: A promising approach for diabetes treatment

E Ghasemi Gojani, S Rai, F Norouzkhani… - Current Issues in …, 2024 - mdpi.com
The β-cells within the pancreas play a pivotal role in insulin production and secretion,
responding to fluctuations in blood glucose levels. However, factors like obesity, dietary …

Metabolite profiles of diabetes mellitus and response to intervention in anti-hyperglycemic drugs

Y Liu, D Wang, YP Liu - Frontiers in Endocrinology, 2023 - frontiersin.org
Type 2 diabetes mellitus (T2DM) has become a major health problem, threatening the
quality of life of nearly 500 million patients worldwide. As a typical multifactorial metabolic …

New insights into the inter-organ crosstalk mediated by ChREBP

T Carbinatti, M Régnier, L Parlati… - Frontiers in …, 2023 - frontiersin.org
Carbohydrate response element binding protein (ChREBP) is a glucose responsive
transcription factor recognized by its critical role in the transcriptional control of glycolysis …

Transcriptional activation of the Myc gene by glucose in β-cells requires a ChREBP-dependent 3-D chromatin interaction between the Myc and Pvt1 genes

LS Katz, G Brill, P Wang, L Lambertini, P Zhang… - Molecular …, 2024 - Elsevier
Objective All forms of diabetes result from insufficient functional β-cell mass. Thus, achieving
the therapeutic goal of expanding β-cell mass requires a better mechanistic understanding …

Disruption of perinatal myeloid niches impacts the aging clock of pancreatic β cells

J O'Sell, V Cirulli, S Pardike, M Aare-Bentsen, P Sdek… - Iscience, 2024 - cell.com
Perinatal expansion of pancreatic β cells is critical to metabolic adaptation. Yet, mechanisms
surveying the fidelity by which proliferative events generate functional β cell pools remain …

Mbnl1-mediated alternative splicing of circMlxipl regulates Rbbp6-involved ChREBP turnover to inhibit lipotoxicity-induced β-cell damage

Y Gong, M Wei, X Cao, C Xu, J Jin, L Pei, Y Li… - Molecular …, 2024 - Springer
Background Diabetes, a global epidemic, is the leading cause of mortality globally. The aim
of this study is to get better understanding of pathophysiology of diabetes. Methods Palmitic …

[HTML][HTML] Insulin receptor-inspired soluble insulin binder

C Mendoza, C Hanegan, A Sperry, L Vargas… - European Journal of …, 2023 - Elsevier
The insulin receptor (IR) is a 320 kDa membrane receptor tyrosine kinase mediating the
pleiotropic actions of insulin, leading to phosphorylation of several intracellular substrates …