Members of the highly conserved and ubiquitously expressed pleiotropic CK1 family play
major regulatory roles in many cellular processes including DNA-processing and repair …

The CK1 family of serine/threonine kinases regulates diverse cellular processes, through
binding to and phosphorylation a myriad of protein substrates. CK1 prefers substrates …

NLRP3 controls the secretion of inflammatory cytokines IL-1β/18 and pyroptosis by
assembling the inflammasome. Upon coordinated priming and activation stimuli, NLRP3 …

Tumor-derived extracellular vesicles (TEV)" educate" healthy cells to promote metastases.
We found that melanoma TEV downregulated type I interferon (IFN) receptor and expression …

Casein kinase 1α (CK1α) is a multifunctional protein belonging to the CK1 protein family that
is conserved in eukaryotes from yeast to humans. It regulates signaling pathways related to …

Type I interferons (IFNs) comprise of pro-inflammatory cytokines created, as well as sensed,
by all nucleated cells with the main objective of blocking pathogens-driven infections. Owing …

Members of the highly conserved pleiotropic CK1 family of serine/threonine-specific kinases
are tightly regulated in the cell and play crucial regulatory roles in multiple cellular …

Leishmania is a protozoan parasite of the trypanosomatid family, causing a wide range of
diseases with different clinical manifestations including cutaneous, mucocutaneous and …

The unfolded protein response (UPR) is an ensemble of signal transduction pathways that
respond to perturbations in the oxidative, pro-folding environment of the endoplasmic …

The state of antileishmanial chemotherapy is strongly compromised by the emergence of
drug-resistant Leishmania. The evolution of drug-resistant phenotypes has been linked to …