Since the elucidation of the molecular structure of nucleic acids and understanding of their
role in encoding and translating genetic information into biological function, 1 the knowledge …

Gene therapy offers great opportunities for the treatment of severe diseases including
cancer. In recent years the design of synthetic carriers for nucleic acid delivery has become …

Altered vasculature and the resultant chaotic tumor blood flow lead to the appearance in fast‐
growing tumors of regions with gradients of oxygen tension and acute hypoxia (less than …

The discovery of RNA interference (RNAi) as a naturally occurring mechanism for gene
knockdown has attracted considerable attention toward the use of small interfering RNAs …

Inhaled gene carriers must penetrate the highly viscoelastic and adhesive mucus barrier in
the airway in order to overcome rapid mucociliary clearance and reach the underlying …

Gene silencing using small interfering RNA (siRNA) has several potential therapeutic
applications. In the present study, we investigated nanoparticles formulated using the …

The ability to deliver nucleic acids (eg, plasmid DNA, antisense oligonucleotides, siRNA)
offers the potential to develop potent vaccines and novel therapeutics. However, nucleic …

Low efficiency, significant toxicity, polymer polydispersity and poorly understood delivery
mechanisms have initially plagued the field of polymer-based gene therapy. Numerous …

RNA interference (RNAi)-based strategies that mediate the specific knockdown of target
genes by administration of small interfering RNAs (siRNAs) could be applied for treatment of …

There is growing interest in PEGylation of cationic polymeric vehicles for gene delivery in
order to improve vehicle stability and reduce toxicity, but little is known about the effects of …