Abstract (Hetero) arenes continue to prove their indispensability in pharmaceuticals,
materials science, and synthetic chemistry. As such, the controllable modification of …

Skeletal ring enlargement is gaining renewed interest in synthetic chemistry and has
recently focused on insertion of one or two atoms. Strategies for heterocyclic expansion …

Skeletal editing is a straightforward synthetic strategy for precise substitution or
rearrangement of atoms in core ring structures of complex molecules; it enables quick …

Unimolecular fragment coupling (UFC) is defined as a reaction format, wherein atom (s)
located in the middle of a molecule are extruded, and the remaining fragments are coupled …

Skeletal editing has received unprecedented attention as an emerging technology for the
late-stage manipulation of molecular scaffolds. The direct achievement of functionalized …

In this report, we developed a unified and standardized one-pot sequence that converts
pyridine derivatives into 1, 2-diazepines by inserting a nitrogen atom. This skeletal …

We demonstrate that arylchlorodiazirines serve as photo‐activated halocarbene precursors
for the selective one‐carbon ring expansion of N‐substituted pyrroles and indoles to the …

Recent advances in single-atom insertion reactions have opened up new synthetic
approaches for molecular diversification. Developing innovative strategies to directly …

The skeletal ring expansion of heteroarenes through carbene insertion is gaining popularity
in synthetic chemistry. Efficient strategies for heterocyclic ring expansion to access …

Fluorinated quinolines and pyridines are prevalent pharmacophores, yet their synthesis is
often challenging. Herein, we demonstrate that dibromofluoromethane as …