A framework for designing delivery systems
The delivery of medical agents to a specific diseased tissue or cell is critical for diagnosing
and treating patients. Nanomaterials are promising vehicles to transport agents that include …
and treating patients. Nanomaterials are promising vehicles to transport agents that include …
Tissue optical clearing for 3D visualization of vascular networks: A review
J Zhu, X Liu, Y Deng, D Li, T Yu, D Zhu - Vascular Pharmacology, 2021 - Elsevier
Reconstruction of the vasculature of intact tissues/organs down to the capillary level is
essential for understanding the development and remodeling of vascular networks under …
essential for understanding the development and remodeling of vascular networks under …
3D microfluidic platform and tumor vascular mapping for evaluating anti-angiogenic RNAi-based nanomedicine
Three-dimensional (3D) visualization of tumor vasculature is a key factor in accurate
evaluation of RNA interference (RNAi)-based antiangiogenic nanomedicine, a promising …
evaluation of RNA interference (RNAi)-based antiangiogenic nanomedicine, a promising …
Enhancement of gene editing and base editing with therapeutic ribonucleoproteins through in vivo delivery based on absorptive silica nanoconstruct
Key to the widespread and secure application of genome editing tools is the safe and
effective delivery of multiple components of ribonucleoproteins (RNPs) into single cells …
effective delivery of multiple components of ribonucleoproteins (RNPs) into single cells …
Far‐Red Aggregation‐Induced Emission Hydrogel‐Reinforced Tissue Clearing for 3D Vasculature Imaging of Whole Lung and Whole Tumor
Understanding the vascular formation and distribution in metastatic lung tumors is a
significant challenge due to autofluorescence, antibody/dye diffusion in dense tumor, and …
significant challenge due to autofluorescence, antibody/dye diffusion in dense tumor, and …
Volumetric imaging of optically cleared and fluorescently labeled animal tissue (VIOLA) for quantifying the 3D biodistribution of nanoparticles at cellular resolution in …
N Rakhilin, B Yang, ME Spilker, LK Manzuk… - Journal of Controlled …, 2023 - Elsevier
Nanoparticle (NP) technology holds significant promise to mediate targeted drug delivery to
specific organs in the body. Understanding the 3D biodistribution of NPs in heterogeneous …
specific organs in the body. Understanding the 3D biodistribution of NPs in heterogeneous …
Interdependency of influential parameters in therapeutic nanomedicine
SM Kamali Shahri, S Sharifi… - Expert Opinion on Drug …, 2021 - Taylor & Francis
Introduction: Current challenges to successful clinical translation of therapeutic
nanomedicine have discouraged many stakeholders, including patients. Significant effort …
nanomedicine have discouraged many stakeholders, including patients. Significant effort …
[HTML][HTML] Volume imaging to interrogate cancer cell-tumor microenvironment interactions in space and time
Volume imaging visualizes the three-dimensional (3D) complexity of tumors to unravel the
dynamic crosstalk between cancer cells and the heterogeneous landscape of the tumor …
dynamic crosstalk between cancer cells and the heterogeneous landscape of the tumor …
[HTML][HTML] Phosphorescent Ir (III) complexes conjugated with oligoarginine peptides serve as optical probes for in vivo microvascular imaging
M Yasukagawa, A Shimada, S Shiozaki, S Tobita… - Scientific Reports, 2021 - nature.com
Imaging the vascular structures of organ and tumor tissues is extremely important for
assessing various pathological conditions. Herein we present the new vascular imaging …
assessing various pathological conditions. Herein we present the new vascular imaging …
A High‐Resolution Prediction Network for Predicting Intratumoral Distribution of Nanoprobes by Tumor Vascular and Nuclear Feature
J Xu, Y Luo, C Wang, H Chen, Y Tang… - Advanced Intelligent …, 2024 - Wiley Online Library
In this study, the critical need for precise and accurate prediction of intra‐tumor
heterogeneity related to the enhanced permeability and retention effect and spatial …
heterogeneity related to the enhanced permeability and retention effect and spatial …