Therapeutic drug monitoring (TDM) is the quantification and interpretation of drug
concentrations in blood to optimize pharmacotherapy. It considers the interindividual …

Therapeutic drug monitoring (TDM), ie, the quantification of serum or plasma concentrations
of medications for dose optimization, has proven a valuable tool for the patient-matched …

Antiepileptic drugs (AEDs) are the mainstay in the treatment of epilepsy, one of the most
common serious chronic neurological disorders. AEDs display extensive pharmacological …

Pharmacogenomics can identify polymorphisms in genes involved in drug pharmacokinetics
and pharmacodynamics determining differences in efficacy and safety and causing inter …

As a chronic brain disease, epilepsy affects~ 50 million people worldwide. The traditional
antiepileptic drugs (AEDs) are widely applied but showing various problems. Although the …

Given the CYP3A4 and CYP3A5's impact on the efficacy of drugs, the genetic backgrounds
of individuals and populations are regarded as an important factor to be considered in the …

Carbamazepine (CBZ), a dibenzazepine, is a tricyclic compound used in the treatment of
epilepsy, trigeminal neuralgia, and psychiatric mood disorders [1]. Serious adverse events …

Aim The present study aimed to evaluate the effects of gene variants in key genes
influencing pharmacokinetic and pharmacodynamic of carbamazepine (CBZ) on the …

This chapter includes the aspects of carbamazepine. The drug is synthesized by the use of
5H-dibenz [b, f] azepine and phosgene followed by subsequent reaction with ammonia …

Multidrug resistance P-glycoprotein (P-gp; also known as MDR1 and ABCB1) is expressed
in the luminal membrane of the small intestine and blood–brain barrier, and the apical …