[HTML][HTML] The PTGS2/COX2-PGE2 signaling cascade in inflammation: Pro or anti? A case study with type 1 diabetes mellitus

E Martín-Vázquez, N Cobo-Vuilleumier… - … journal of biological …, 2023 - ncbi.nlm.nih.gov
Prostaglandins are lipid mediators involved in physiological processes, such as constriction
or dilation of blood vessels, but also pathophysiological processes, which include …

Regulatory T cell and macrophage crosstalk in acute lung injury: future perspectives

T Guan, X Zhou, W Zhou, H Lin - Cell death discovery, 2023 - nature.com
Acute lung injury (ALI) describes the injury to endothelial cells in the lungs and associated
vessels due to various factors. Furthermore, ALI accompanied by inflammation and …

Prostanoids and resolution of inflammation–beyond the lipid-mediator class switch

T Schmid, B Brüne - Frontiers in immunology, 2021 - frontiersin.org
Bioactive lipid mediators play a major role in regulating inflammatory processes. Herein,
early pro-inflammatory phases are characterized and regulated by prostanoids and …

Biomarkers of endometriosis

A Pant, K Moar, TK Arora, PK Maurya - Clinica chimica acta, 2023 - Elsevier
Endometriosis is one of the most severe female reproductive disorders, affecting 6–10% of
women between 18 and 35. It is a gynaecological condition where endometrial tissue …

[HTML][HTML] Non-classical circulating monocytes expressing high levels of microsomal prostaglandin E2 synthase-1 tag an aberrant IFN-response in systemic sclerosis

G Villanueva-Martin, M Acosta-Herrera… - Journal of …, 2023 - Elsevier
Systemic sclerosis (SSc) is a complex disease that affects the connective tissue, causing
fibrosis. SSc patients show altered immune cell composition and activation in the peripheral …

Gingerenone A Attenuates Ulcerative Colitis via Targeting IL‐17RA to Inhibit Inflammation and Restore Intestinal Barrier Function

J Liang, W Dai, C Liu, Y Wen, C Chen, Y Xu… - Advanced …, 2024 - Wiley Online Library
Ulcerative colitis (UC) is a complicated and recurrent intestinal disease. Currently available
drugs for UC treatment are scarce, therefore, novel therapeutic drugs for the UC are urgently …

Microsomal prostaglandin E2 synthase-1 and its inhibitors: Molecular mechanisms and therapeutic significance

YY Zhang, YD Yao, JF Luo, ZQ Liu, YM Huang… - Pharmacological …, 2022 - Elsevier
Inflammation is closely linked to the abnormal phospholipid metabolism chain of
cyclooxygenase-2/microsomal prostaglandin E 2 synthase-1/prostaglandin E 2 (COX …

Anti-inflammatory and immunomodulatory activity of Mangifera indica L. reveals the modulation of COX-2/mPGES-1 axis and Th17/Treg ratio

A Saviano, F Raucci, GM Casillo, AA Mansour… - Pharmacological …, 2022 - Elsevier
In the context of inflammation and immunity, there are fragmented and observational studies
relating to the pharmacological activity of Mangifera indica L. and its main active component …

PARP inhibition promotes endothelial‐like traits in melanoma cells and modulates pericyte coverage dynamics during vasculogenic mimicry

M Fernández‐Cortés, D Delgado‐Bellido… - The Journal of …, 2023 - Wiley Online Library
Vasculogenic mimicry (VM) describes the ability of highly aggressive tumor cells to develop
pseudovascular structures without the participation of endothelial cells. PARP1 is implicated …

Analysis of rheumatoid-vs psoriatic arthritis synovial fluid reveals differential macrophage (CCR2) and T helper subsets (STAT3/4 and FOXP3) activation.

F Caso, A Saviano, M Tasso, F Raucci… - Autoimmunity …, 2022 - Elsevier
Abstract Objective In psoriatic arthritis (PsA) and rheumatoid arthritis (RA), inflammatory
responses are characterized by increased production of pro-inflammatory molecules …