[HTML][HTML] APOE mediated neuroinflammation and neurodegeneration in Alzheimer's disease
S Parhizkar, DM Holtzman - Seminars in immunology, 2022 - Elsevier
Neuroinflammation is a central mechanism involved in neurodegeneration as observed in
Alzheimer's disease (AD), the most prevalent form of neurodegenerative disease …
Alzheimer's disease (AD), the most prevalent form of neurodegenerative disease …
Computational models link cellular mechanisms of neuromodulation to large-scale neural dynamics
Decades of neurobiological research have disclosed the diverse manners in which the
response properties of neurons are dynamically modulated to support adaptive cognitive …
response properties of neurons are dynamically modulated to support adaptive cognitive …
Microglial activation and tau propagate jointly across Braak stages
Compelling experimental evidence suggests that microglial activation is involved in the
spread of tau tangles over the neocortex in Alzheimer's disease (AD). We tested the …
spread of tau tangles over the neocortex in Alzheimer's disease (AD). We tested the …
A practical guide to linking brain-wide gene expression and neuroimaging data
The recent availability of comprehensive, brain-wide gene expression atlases such as the
Allen Human Brain Atlas (AHBA) has opened new opportunities for understanding how …
Allen Human Brain Atlas (AHBA) has opened new opportunities for understanding how …
[HTML][HTML] Generative modeling of brain maps with spatial autocorrelation
Studies of large-scale brain organization have revealed interesting relationships between
spatial gradients in brain maps across multiple modalities. Evaluating the significance of …
spatial gradients in brain maps across multiple modalities. Evaluating the significance of …
APOE4 is associated with cognitive and pathological heterogeneity in patients with Alzheimer's disease: a systematic review
S Emrani, HA Arain, C DeMarshall, T Nuriel - Alzheimer's research & …, 2020 - Springer
Possession of the ε4 allele of apolipoprotein E (APOE) is the primary genetic risk factor for
the sporadic form of Alzheimer's disease (AD). While researchers have extensively …
the sporadic form of Alzheimer's disease (AD). While researchers have extensively …
Neuronal timescales are functionally dynamic and shaped by cortical microarchitecture
Complex cognitive functions such as working memory and decision-making require
information maintenance over seconds to years, from transient sensory stimuli to long-term …
information maintenance over seconds to years, from transient sensory stimuli to long-term …
APOEε4 associates with microglial activation independently of Aβ plaques and tau tangles
Animal studies suggest that the apolipoprotein E ε4 (APOE ε4) allele is a culprit of early
microglial activation in Alzheimer's disease (AD). Here, we tested the association between …
microglial activation in Alzheimer's disease (AD). Here, we tested the association between …
Association of apolipoprotein E ε4 with medial temporal tau independent of amyloid-β
Importance Apolipoprotein E ε4 (APOEε4) is the single most important genetic risk factor for
Alzheimer disease. WhileAPOEε4is associated with increased amyloid-β burden, its …
Alzheimer disease. WhileAPOEε4is associated with increased amyloid-β burden, its …
APOE ε4 genotype, amyloid-β, and sex interact to predict tau in regions of high APOE mRNA expression
The apolipoprotein E (APOE) ε4 allele is strongly linked with cerebral β-amyloidosis, but its
relationship with tauopathy is less established. We investigated the relationship between …
relationship with tauopathy is less established. We investigated the relationship between …