Metabolic changes in aging humans: current evidence and therapeutic strategies

AK Palmer, MD Jensen - The Journal of clinical …, 2022 - Am Soc Clin Investig
Aging and metabolism are inextricably linked, and many age-related changes in body
composition, including increased central adiposity and sarcopenia, have underpinnings in …

Obesity and heart failure with preserved ejection fraction: new insights and pathophysiological targets

BA Borlaug, MD Jensen, DW Kitzman… - Cardiovascular …, 2022 - academic.oup.com
Obesity and heart failure with preserved ejection fraction (HFpEF) represent two
intermingling epidemics driving perhaps the greatest unmet health problem in …

Sex differences in human adipose tissues–the biology of pear shape

K Karastergiou, SR Smith, AS Greenberg… - Biology of sex …, 2012 - Springer
Women have more body fat than men, but in contrast to the deleterious metabolic
consequences of the central obesity typical of men, the pear-shaped body fat distribution of …

[HTML][HTML] Mechanisms and metabolic implications of regional differences among fat depots

T Tchkonia, T Thomou, YI Zhu, I Karagiannides… - Cell metabolism, 2013 - cell.com
Fat distribution is closely linked to metabolic disease risk. Distribution varies with sex,
genetic background, disease state, certain drugs and hormones, development, and aging …

Adipocyte mitochondrial function is reduced in human obesity independent of fat cell size

X Yin, IR Lanza, JM Swain, MG Sarr… - The Journal of …, 2014 - academic.oup.com
Context: It has been suggested that mitochondrial dysfunction in adipocytes contributes to
obesity-related metabolic complications. However, obesity results in adipocyte hypertrophy …

Chronic intermittent hypoxia induces atherosclerosis via activation of adipose angiopoietin-like 4

LF Drager, Q Yao, KL Hernandez, MK Shin… - American journal of …, 2013 - atsjournals.org
Rationale: Obstructive sleep apnea is a risk factor for dyslipidemia and atherosclerosis,
which have been attributed to chronic intermittent hypoxia (CIH). Intermittent hypoxia inhibits …

The role of chronic inflammation in obesity‐associated cancers

ME Ramos-Nino - International Scholarly Research Notices, 2013 - Wiley Online Library
There is a strong relationship between metabolism and immunity, which can become
deleterious under conditions of metabolic stress. Obesity, considered a chronic inflammatory …

Comparison of a bioelectrical impedance device against the reference method dual energy X-ray absorptiometry and anthropometry for the evaluation of body …

K Day, A Kwok, A Evans, F Mata, A Verdejo-Garcia… - Nutrients, 2018 - mdpi.com
This study aimed to compare the use of the bioelectrical impedance device (BIA) seca®
mBCA 515 using dual X-ray absorptiometry (DXA) as a reference method, for body …

Detrimental and protective fat: body fat distribution and its relation to metabolic disease

A Booth, A Magnuson, M Foster - Hormone molecular biology and …, 2014 - degruyter.com
Obesity is linked to numerous comorbidities that include, but are not limited to, glucose
intolerance, insulin resistance, dyslipidemia, and cardiovascular disease. Current evidence …

Free fatty acid uptake in humans with CD36 deficiency

KC Hames, A Vella, BJ Kemp, MD Jensen - Diabetes, 2014 - Am Diabetes Assoc
Animal models have demonstrated that CD36 facilitates cell membrane free fatty acid (FFA)
transport, but its role in human metabolism is not well understood. We measured heart, liver …