Chagas disease, leishmaniasis and schistosomiasis are neglected diseases (NDs) and are
a considerable global challenge. Despite the huge number of people infected, NDs do not …

Chagas disease, also known as American trypanosomiasis, is one of the 17 neglected
tropical diseases (NTDs) according to World Health Organization. It is estimated that 8–10 …

Thiazole, thiosemicarbazone and semicarbazone moieties are privileged scaffolds (acting
as primary pharmacophores) in many compounds that are useful to treat several diseases …

Urease is an important enzyme which breaks urea into ammonia and carbon dioxide during
metabolic processes. However, an elevated activity of urease causes various complications …

Chagas disease is a major public health problem caused by Trypanosoma cruzi, with an
estimated 6–7 million people infected and 70 million at risk of infection. T. brucei gambiense …

Background: Privileged motifs are recurring in a wide range of biologically active
compounds that reach different pharmaceutical targets and pathways and could represent a …

Although the parasitic infection Chagas' disease was described over 100 years ago, even
now there are not suitable drugs. The available drugs nifurtimox and benznidazole have …

Triosephosphate isomerase (TIM) is an essential Trypanosoma cruzi enzyme and one of the
few validated drug targets for Chagas disease. The known inhibitors of this enzyme behave …

To develop novel chemotherapeutic alternatives for the treatment of Chagas disease, in this
study, a set of new amino naphthoquinone derivatives were synthesised and evaluated in …

The present work reports the synthesis of a novel series of pyridine-thiazolidinones with anti-
Trypanosoma cruzi and leishmanicidal activities (compounds 10–27), derived from 2 or 4 …