The catalytic functionalization of unreactive C− H bonds has recently brought a revolution in
synthetic methodologies for the production of pharmaceuticals and natural products and for …

To improve the atom-and step-economy of organic syntheses, researchers would like to
capitalize upon the chemistry of otherwise inert carbon–hydrogen (C–H) bonds. During the …

Manganese is found in the active center of numerous enzymes that operate by an outer-
sphere homolytic C–H cleavage. Thus, a plethora of bioinspired radical-based C–H …

Synthetically useful functional groups, including ketones, amides, carbamates, carboxylic
acids, aldehydes or ethers, have been identified as weakly coordinating directing groups in …

The transition metal-catalyzed transformation of otherwise inert C–H bonds into substituted
alkenes offers a versatile tool for the synthesis of value added olefinic molecules. Recent …

Functionalization of unactivated carbon–hydrogen (C–H) single bonds is an efficient
strategy for rapid generation of complex molecules from simpler ones. However, it is difficult …

Ever‐evolving catalyst advances in synthetic protocols using water as a reaction medium
have enriched the understanding of sustainable organic chemistry. Because conventional …

Achieving site selectivity in carbon–hydrogen (C–H) functionalization reactions is a long-
standing challenge in organic chemistry. The small differences in intrinsic reactivity of C–H …

The development of new strategies and chemical reactions continues to be a major focus of
research efforts in the modern synthetic organic community. 1 Of the various types of …

The selective transformation of C− H bonds is one of the most desirable approaches to
creating complexity from simple building blocks. Several directing groups are efficient in …