Pain is a multidimensional experience with sensory-discriminative, affective-motivational,
and cognitive-evaluative components. Pain aversiveness is one principal cause of suffering …

Chronic, pathological pain remains a global health problem and a challenge to basic and
clinical sciences. A major obstacle to preventing, treating, or reverting chronic pain has been …

Injury to or disease of the nervous system can invoke chronic and sometimes intractable
neuropathic pain. Many parallel, interdependent, and time-dependent processes, including …

Chronic pain affects a large part of the population causing functional disability, being often
associated with coexisting psychological disorders, such as depression and anxiety …

Chronic pain is a complex neuropsychiatric disorder characterized by sensory, cognitive,
and affective symptoms. Over the past 2 decades, researchers have made significant …

Sound—including music and noise—can relieve pain in humans, but the underlying neural
mechanisms remain unknown. We discovered that analgesic effects of sound depended on …

Abstract Machine learning is a powerful tool for creating computational models relating brain
function to behavior, and its use is becoming widespread in neuroscience. However, these …

Pain has a strong emotional component and is defined by its unpleasantness. Chronic pain
represents a complex disorder with anxio-depressive symptoms and cognitive deficits …

Negative affective states affect quality of life for patients suffering from pain. These
maladaptive emotional states can lead to involuntary opioid overdose and many …

Cerebral processes contribute to pain beyond the level of nociceptive input and mediate
psychological and behavioural influences. However, cerebral contributions beyond …