Natural alternatives targeting psoriasis pathology and key signaling pathways: A focus on phytochemicals

IK Koycheva, AS Marchev, ID Stoykova… - Phytochemistry …, 2023 - Springer
Psoriasis is an autoimmune, chronic skin disorder with complex and yet unclear
pathogenesis. It is associated with many conditions, including psoriatic arthritis …

Coptisine, the Characteristic Constituent from Coptis chinensis, Exhibits Significant Therapeutic Potential in Treating Cancers, Metabolic and Inflammatory Diseases

Q Lu, Y Tang, S Luo, Q Gong, C Li - The American Journal of …, 2023 - World Scientific
Naturally derived alkaloids belong to a class of quite significant organic compounds.
Coptisine, a benzyl tetrahydroisoquinoline alkaloid, is one of the major bioactive …

[HTML][HTML] GPR97 depletion aggravates imiquimod-induced psoriasis pathogenesis via amplifying IL-23/IL-17 axis signal pathway

Y Gao, W Zhan, D Guo, H Lin, MA Farooq, C Jin… - Biomedicine & …, 2024 - Elsevier
Skin psoriasis is defined as receiving external stimulation to activate skin dendritic cells
(DCs) which can release interleukin 23 (IL-23) to interlink the innate and adaptive immunity …

FOSL1 regulates hyperproliferation and NLRP3-mediated inflammation of psoriatic keratinocytes through the NF-kB signaling via transcriptionally activating TRAF3

Y Liang, D Han, S Zhang, L Sun - … et Biophysica Acta (BBA)-Molecular Cell …, 2024 - Elsevier
Psoriasis is a common and immune-mediated skin disease related to keratinocytes
hyperproliferation and inflammation. Fos-like antigen-1 (FOSL1) is an important transcription …

Wound healing efficacy of Cannabis sativa L. essential oil in a mouse incisional wound model: A possible link with stress and anxiety

S El Ghacham, I El Bakali, MA Zarouki, YAEH Ali… - South African Journal of …, 2023 - Elsevier
Abstract Cannabis Sativa L.(Cannabaceae) exerts biological effects through its bioactive
compounds. Cannabis Sativa L. essential oil (CSEO) is known to have antibacterial …

Graphene quantum dots based on cannabis seeds for efficient wound healing in a mouse incisional wound model: Link with stress and neurobehavioral effect

MA Zarouki, L Tamegart, L Hejji, YAEH Ali… - International Journal of …, 2024 - Elsevier
Graphene quantum dots (GQDs) are promising biomaterials with potential applicability in
several areas due to their many useful and unique features. Among different applications …

TFAP2C exacerbates psoriasis-like inflammation by promoting Th17 and Th1 cells activation through regulating TEAD4 transcription

H Zhang, C Ren, Q Liu, Q Wang… - Allergologia et …, 2023 - all-imm.com
Background: Psoriasis is one of the chronic and autoimmune skin diseases. It is important to
uncover the mechanisms underlying the psoriasis. Transcription factor activator protein …

Extracellular CIRP Upregulates Proinflammatory Cytokine Expression via the NF‐kappaB and ERK1/2 Signaling Pathways in Psoriatic Keratinocytes

X Zhang, S Wang, W Wang, L Song… - Mediators of …, 2022 - Wiley Online Library
Psoriasis is a chronic inflammatory skin disease, and elevation of proinflammatory cytokine
levels is a critical driver of the pathogenesis of psoriasis. Extracellular cold‐inducible RNA …

Research progress on antidepressant effects and mechanisms of berberine

Y Gao, K Nie, H Wang, H Dong, Y Tang - Frontiers in Pharmacology, 2024 - frontiersin.org
Depression, a global health problem with growing prevalence, brings serious impacts on the
daily life of patients. However, the antidepressants currently used in clinical are not perfectly …

[HTML][HTML] Exploring the mechanism of Huanglian ointment in alleviating wound healing after anal fistula surgery through metabolomics and proteomics

D Zhang, J Gu, Y Xu, X Yu, H Jin - Heliyon, 2024 - cell.com
Anal fistula is a common anal and intestinal disease. The wound of anal fistula surgery is
open and polluting, which is the most difficult to heal among all surgical incisions. To …