As the global eradication of wild poliovirus nears, the World Health Organization (WHO) is
addressing challenges unprecedented in public health. The live, attenuated oral poliovirus …

Enterovirus-induced infection of the central nervous system (CNS) results in acute
inflammation of the brain (encephalitis) and constitutes a significant global burden to human …

Vaccination with Sabin, a live attenuated oral polio vaccine (OPV), results in robust intestinal
and humoral immunity and has been key to controlling poliomyelitis. As with any RNA virus …

Background Use of oral live-attenuated polio vaccines (OPV), and injected inactivated polio
vaccines (IPV) has almost achieved global eradication of wild polio viruses. To address the …

The dynamics of proliferation of large genomic RNA molecules which carry the polio virus
are investigated using new techniques. Genetic variation and identity conservation of …

Poliovirus was first isolated nearly 100 years ago in a landmark experiment that established
the viral etiology of poliomyelitis. This discovery stimulated investigation of the pathogenesis …

Enormous progress has been made in global efforts to eradicate poliovirus, using live-
attenuated Sabin oral poliovirus vaccine (OPV). However, as the incidence of disease due to …

Paralytic polio once afflicted almost half a million children each year. The attenuated oral
polio vaccine (OPV) has enabled world-wide vaccination efforts, which resulted in nearly …

Human enteroviruses have traditionally been typed according to neutralization serotype.
This procedure is limited by the difficulty in culturing some enteroviruses, the availability of …

ABSTRACT From 1988 to 1993, 30 cases of poliomyelitis associated with poliovirus type 2
were found in seven governorates of Egypt. Because many of the cases were …