CC chemokines (or β-chemokines) are 28 chemotactic cytokines with an N-terminal CC
domain that play an important role in immune system cells, such as CD4+ and CD8+ …

The lymphatic system is comprised of a network of vessels interrelated with lymphoid tissue,
which has the holistic function to maintain the local physiologic environment for every cell in …

Sixteen years ago, the Nomenclature Committee of the International Union of Pharmacology
approved a system for naming human seven-transmembrane (7TM) G protein-coupled …

Purpose: T-cell recruitment, survival, and proliferation are the important limitations to
chimeric antigen receptor (CAR) T cells therapy in the treatment of solid tumors. In this study …

The proper function of immune surveillance requires well-coordinated mechanisms in order
to guide the patrolling immune cells through peripheral tissues and into secondary lymphoid …

During the last five years, the development of bioinformatics and EST databases has been
primarily responsible for the identification of many new chemokines and chemokine …

Leukocyte traffic through secondary lymphoid tissues is finely tuned by chemokines. We
have studied the functional properties of a human T cell subset marked by the expression of …

Prolonged lung pathology has been associated with COVID-19, yet the cellular and
molecular mechanisms behind this chronic inflammatory disease are poorly understood. In …

In contrast to the remarkable chemokine responses of phagocytes and monocytes that were
documented early on, lymphocytes have been considered for a long time to be poor targets …

Follicular helper T (TFH) cells are essential for B-cell maturation and immunoglobulin
production after immunization with thymus-dependent antigens. Nevertheless, the …