Mass spectrometry-based biomolecular analyses have become permanent fixtures of
academic, industrial, and clinical research settings. The rise in utilization of mass …

The ability to map a proteomic fingerprint to transcriptomic data would master the
understanding of how gene expression translates into actual phenotype. In contrast to …

The analysis of ultralow input samples or even individual cells is essential to answering a
multitude of biomedical questions, but current proteomic workflows are limited in their …

We describe deep analysis of the human proteome in less than 1 h. We achieve this
expedited proteome characterization by leveraging state-of-the-art sample preparation …

The proteome, or collection of proteoforms expressed in a biological system, is dynamic and
heterogeneous. As our appreciation for the complexity of the proteome has evolved, so have …

Recently, we presented the DirectMS1 method of ultrafast proteome-wide analysis based on
minute-long LC gradients and MS1-only mass spectra acquisition. Currently, the method …

Omics technologies focus on uncovering the complex nature of molecular mechanisms in
cells and organisms, including biomarkers and drug targets discovery. Aiming at these tasks …

Clinical proteomics analysis is of great significance for analyzing pathological mechanisms
and discovering disease-related biomarkers. Using computational methods to accurately …

Chemical proteomics, emerging rapidly in recent years, has become a main approach to
identifying interactions between the small molecules and proteins in the cells on a proteome …

Proteome analysis currently heavily relies on tandem mass spectrometry (MS/MS), which
does not fully utilize MS1 features, as many precursors remain unselected for MS/MS …